Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Six patients with Parkinson's disease were followed for 10 to 72 months after human embryonic mesencephalic tissue from four to seven donors was grafted unilaterally into the putamen (4 patients) or putamen plus caudate (2 patients). After 8 to 12 months, positron emission tomography showed a 68% increase of 6-L-[18F]-fluorodopa uptake in the grafted putamen, no change in the grafted caudate, and minor decreases in nongrafted striatal regions. There was therapeutically valuable improvement in 4 patients, but only modest changes in the other 2, both of whom developed atypical features. Patient 4 was without L-dopa from 32 months and had normal fluorodopa uptake in the grafted putamen at 72 months. Overall, the L-dopa dose was reduced by a mean of 10 and 20%, "off" time was reduced by 34 and 44%, and the "off" phase Unified Parkinson's Disease Rating Scale motor score by 18 and 26%, and the duration of the response to a single L-dopa dose increased by 45 and 58% during the first and second years after surgery, respectively. Rigidity and hypokinesia improved bilaterally, but mainly contralateral to the implant. No consistent changes in dyskinesias were observed. We conclude that transplantation of embryonic mesencephalic tissue leads to highly reproducible survival of dopaminergic neurons, inducing clinically valuable improvements in most recipients.

Detaljer

Författare
  • Gregor K Wenning
  • Per Odin
  • Paul Morrish
  • Stig Rehncrona
  • Håkan Widner
  • Patrik Brundin
  • John C Rothwell
  • Richard Brown
  • Björn Gustavii
  • Peter Hagell
  • Marjan Jahanshahi
  • Guy Sawle
  • Anders Björklund
  • David J Brooks
  • C David Marsden
  • Niall P Quinn
  • Olle Lindvall
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper
  • Neurologi
Originalspråkengelska
Sidor (från-till)95-107
TidskriftAnnals of Neurology
Volym42
Utgivningsnummer1
StatusPublished - 1997
PublikationskategoriForskning
Peer review utfördJa