Single DNA conformations and biological function

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

From a nanoscience perspective, cellular processes and their reduced in vitro imitations provide extraordinary examples for highly robust few or single molecule reaction pathways. A prime example are biochemical reactions involving DNA molecules, and the coupling of these reactions to the physical conformations of DNA. In this review, we summarise recent results on the following phenomena: We investigate the biophysical properties of DNA-looping and the equilibrium configurations of DNA-knots, whose relevance to biological processes are increasingly appreciated. We discuss how random DNA-looping may be related to the efficiency of the target search process of proteins for their specific binding site on the DNA molecule. And we dwell on the spontaneous formation of intermittent DNA nanobubbles and their importance for biological processes, such as transcription initiation. The physical properties of DNA may indeed turn out to be particularly suitable for the use of DNA in nanosensing applications.

Detaljer

Författare
Externa organisationer
  • Nordita, det Nordiska institutet för teoretisk fysik
  • University of Ottawa
  • Massachusetts Institute of Technology
  • University of Texas at Brownsville and Texas Southmost College
  • The University of Texas at Dallas
  • Lawrence Berkeley National Laboratory
Forskningsområden

Nyckelord

Originalspråkengelska
Sidor (från-till)1-49
Antal sidor49
TidskriftJournal of Computational and Theoretical Nanoscience
Volym4
Utgivningsnummer1
StatusPublished - 2007 jan 1
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa