Single DNA conformations and biological function

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Single DNA conformations and biological function. / Metzler, Ralf; Ambjörnsson, Tobias; Hanke, Andreas; Zhang, Yongli; Levene, Stephen.

I: Journal of Computational and Theoretical Nanoscience, Vol. 4, Nr. 1, 01.01.2007, s. 1-49.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

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Metzler, R, Ambjörnsson, T, Hanke, A, Zhang, Y & Levene, S 2007, 'Single DNA conformations and biological function', Journal of Computational and Theoretical Nanoscience, vol. 4, nr. 1, s. 1-49.

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Metzler, Ralf ; Ambjörnsson, Tobias ; Hanke, Andreas ; Zhang, Yongli ; Levene, Stephen. / Single DNA conformations and biological function. I: Journal of Computational and Theoretical Nanoscience. 2007 ; Vol. 4, Nr. 1. s. 1-49.

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TY - JOUR

T1 - Single DNA conformations and biological function

AU - Metzler, Ralf

AU - Ambjörnsson, Tobias

AU - Hanke, Andreas

AU - Zhang, Yongli

AU - Levene, Stephen

PY - 2007/1/1

Y1 - 2007/1/1

N2 - From a nanoscience perspective, cellular processes and their reduced in vitro imitations provide extraordinary examples for highly robust few or single molecule reaction pathways. A prime example are biochemical reactions involving DNA molecules, and the coupling of these reactions to the physical conformations of DNA. In this review, we summarise recent results on the following phenomena: We investigate the biophysical properties of DNA-looping and the equilibrium configurations of DNA-knots, whose relevance to biological processes are increasingly appreciated. We discuss how random DNA-looping may be related to the efficiency of the target search process of proteins for their specific binding site on the DNA molecule. And we dwell on the spontaneous formation of intermittent DNA nanobubbles and their importance for biological processes, such as transcription initiation. The physical properties of DNA may indeed turn out to be particularly suitable for the use of DNA in nanosensing applications.

AB - From a nanoscience perspective, cellular processes and their reduced in vitro imitations provide extraordinary examples for highly robust few or single molecule reaction pathways. A prime example are biochemical reactions involving DNA molecules, and the coupling of these reactions to the physical conformations of DNA. In this review, we summarise recent results on the following phenomena: We investigate the biophysical properties of DNA-looping and the equilibrium configurations of DNA-knots, whose relevance to biological processes are increasingly appreciated. We discuss how random DNA-looping may be related to the efficiency of the target search process of proteins for their specific binding site on the DNA molecule. And we dwell on the spontaneous formation of intermittent DNA nanobubbles and their importance for biological processes, such as transcription initiation. The physical properties of DNA may indeed turn out to be particularly suitable for the use of DNA in nanosensing applications.

KW - DNA

KW - DNA denaturation

KW - DNA looping

KW - Gene regulation

KW - Knots

KW - Single molecules

UR - http://www.scopus.com/inward/record.url?scp=34247495997&partnerID=8YFLogxK

M3 - Review article

VL - 4

SP - 1

EP - 49

JO - Journal of Computational and Theoretical Nanoscience

T2 - Journal of Computational and Theoretical Nanoscience

JF - Journal of Computational and Theoretical Nanoscience

SN - 1546-1955

IS - 1

ER -