Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe: An Update on the EPIC Cohorts Study

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

BACKGROUND: To analyze the potential effect of social inequality on pancreatic cancer risk in Western Europe, by reassessing the association within the European Prospective Investigation into Cancer and Nutrition (EPIC) Study, including a larger number of cases and an extended follow-up.

METHODS: Data on highest education attained were gathered for 459,170 participants (70% women) from 10 European countries. A relative index of inequality (RII) based on adult education was calculated for comparability across countries and generations. Cox regression models were applied to estimate relative inequality in pancreatic cancer risk, stratifying by age, gender, and center, and adjusting for known pancreatic cancer risk factors.

RESULTS: A total of 1,223 incident pancreatic cancer cases were included after a mean follow-up of 13.9 (±4.0) years. An inverse social trend was found in models adjusted for age, sex, and center for both sexes [HR of RII, 1.27; 95% confidence interval (CI), 1.02-1.59], which was also significant among women (HR, 1.42; 95% CI, 1.05-1.92). Further adjusting by smoking intensity, alcohol consumption, body mass index, prevalent diabetes, and physical activity led to an attenuation of the RII risk and loss of statistical significance.

CONCLUSIONS: The present reanalysis does not sustain the existence of an independent social inequality influence on pancreatic cancer risk in Western European women and men, using an index based on adult education, the most relevant social indicator linked to individual lifestyles, in a context of very low pancreatic cancer survival from (quasi) universal public health systems.

IMPACT: The results do not support an association between education and risk of pancreatic cancer.

Detaljer

Författare
  • Lluís Cirera
  • José María Huerta
  • María Dolores Chirlaque
  • Kim Overvad
  • Anne Tjønneland
  • Marie-Christine Boutron-Ruault
  • Vinciane Rebours
  • Guy Fagherazzi
  • Verena A Katzke
  • Heiner Boeing
  • Eleni Peppa
  • Antonia Trichopoulou
  • Elissavet Valanou
  • Domenico Palli
  • Sara Grioni
  • Salvatore Panico
  • Rosario Tumino
  • Fulvio Ricceri
  • Carla van Gils
  • Roel C H Vermeulen
  • Guri Skeie
  • Tonje Braaten
  • Elisabete Weiderpass
  • Susana Merino
  • María José Sánchez
  • Nerea Larrañaga
  • Eva Ardanaz
  • Malin Sund
  • Kay-Tee Khaw
  • Timothy J Key
  • Mazda Jenab
  • Sabine Naudin
  • Neil Murphy
  • Dagfinn Aune
  • Heather Ward
  • Elio Riboli
  • Bas Bueno-de-Mesquita
  • Carmen Navarro
  • Eric J Duell
Enheter & grupper
Externa organisationer
  • Aarhus University
  • University of Copenhagen
  • National and Kapodistrian University of Athens
  • University Medical Center Utrecht
  • University of Murcia
  • Murcia Regional Health Council
  • Stabilite genetique et oncogenese
  • Beaujon Hospital
  • German Cancer Research Centre
  • German Institute of Human Nutrition
  • Catalan Institute of Oncology
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Originalspråkengelska
Sidor (från-till)1089-1092
Antal sidor4
TidskriftCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Volym28
Utgåva nummer6
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa