SOCS6 (suppressor of cytokine signaling 6)

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title = "SOCS6 (suppressor of cytokine signaling 6)",
abstract = "The suppressor of cytokine signaling (SOCS) family of proteins are well known negative regulators of cytokine receptors signaling consisting of eight structurally similar proteins, SOCS1-7 and CIS. A key feature of this family of proteins is the presence of two structural motifs: a centrally located SH2 domain and a SOCS box in the C-terminus. The SOCS box mediates the interaction with the Elongins B and C complex while an additional motif mediates its interaction with Cullin 5 to assemble a Cullin/Ring ubiquitin ligase. In this complex SOCS6 acts as a substrate recognition subunit through interactions mediated by the N-terminus and the SH2 domain. SOCS6 interacts with tyrosine kinase receptors FLT3 and c-KIT and modulate their ubiquitination and function.",
keywords = "CIS4, SSI4, CIS-4, SOCS4, STAI4, SOCS-4, SOCS-6, STATI4, HSPC060.",
author = "Kazi, {Julhash U.} and Amilcar Flores-Morales and Lars R{\"o}nnstrand",
year = "2015",
doi = "10.4267/2042/55379",
language = "English",
volume = "19",
pages = "50--52",
journal = "Atlas of Genetics and Cytogenetics in Oncology and Haematology",
issn = "1768-3262",
publisher = "ARMGHM / NIST - CNRS",
number = "1",