SOCS6 (suppressor of cytokine signaling 6)

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SOCS6 (suppressor of cytokine signaling 6). / Kazi, Julhash U.; Flores-Morales, Amilcar; Rönnstrand, Lars.

I: Atlas of Genetics and Cytogenetics in Oncology and Haematology, Vol. 19, Nr. 1, 2015, s. 50-52.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

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TY - JOUR

T1 - SOCS6 (suppressor of cytokine signaling 6)

AU - Kazi, Julhash U.

AU - Flores-Morales, Amilcar

AU - Rönnstrand, Lars

PY - 2015

Y1 - 2015

N2 - The suppressor of cytokine signaling (SOCS) family of proteins are well known negative regulators of cytokine receptors signaling consisting of eight structurally similar proteins, SOCS1-7 and CIS. A key feature of this family of proteins is the presence of two structural motifs: a centrally located SH2 domain and a SOCS box in the C-terminus. The SOCS box mediates the interaction with the Elongins B and C complex while an additional motif mediates its interaction with Cullin 5 to assemble a Cullin/Ring ubiquitin ligase. In this complex SOCS6 acts as a substrate recognition subunit through interactions mediated by the N-terminus and the SH2 domain. SOCS6 interacts with tyrosine kinase receptors FLT3 and c-KIT and modulate their ubiquitination and function.

AB - The suppressor of cytokine signaling (SOCS) family of proteins are well known negative regulators of cytokine receptors signaling consisting of eight structurally similar proteins, SOCS1-7 and CIS. A key feature of this family of proteins is the presence of two structural motifs: a centrally located SH2 domain and a SOCS box in the C-terminus. The SOCS box mediates the interaction with the Elongins B and C complex while an additional motif mediates its interaction with Cullin 5 to assemble a Cullin/Ring ubiquitin ligase. In this complex SOCS6 acts as a substrate recognition subunit through interactions mediated by the N-terminus and the SH2 domain. SOCS6 interacts with tyrosine kinase receptors FLT3 and c-KIT and modulate their ubiquitination and function.

KW - CIS4

KW - SSI4

KW - CIS-4

KW - SOCS4

KW - STAI4

KW - SOCS-4

KW - SOCS-6

KW - STATI4

KW - HSPC060.

U2 - 10.4267/2042/55379

DO - 10.4267/2042/55379

M3 - Review article

VL - 19

SP - 50

EP - 52

JO - Atlas of Genetics and Cytogenetics in Oncology and Haematology

T2 - Atlas of Genetics and Cytogenetics in Oncology and Haematology

JF - Atlas of Genetics and Cytogenetics in Oncology and Haematology

SN - 1768-3262

IS - 1

ER -