Specificity of leucine stimulation of insulin release

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The ability of leucine to stimulate insulin release was studied in an in vitro system, using microdissected pancreatic islets with a high proportion of the insulin-producing β-cells. When tested in a glucose-free medium, l-leucine stimulated insulin release over a wide concentration range with maximum effect at about 20 mm. The stimulation of insulin release was additive to that elicited by 10 mm glucose. The l-configuration was essential for leucine to be recognized by the β-cells as an insulin secretagogue. l-isoleucine, alone or in combination with l-leucine, did not affect insulin release. It seems, therefore, unlikely that all sites for l-leucine transport are identical with receptor sites for stimulation of insulin release.

Detaljer

Författare
Externa organisationer
  • Umeå University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Endokrinologi och diabetes

Nyckelord

Originalspråkengelska
Sidor (från-till)14-21
Antal sidor8
TidskriftHormone Research in Paediatrics
Volym3
Utgåva nummer1
StatusPublished - 1972 jan 1
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa