Specificity of leucine stimulation of insulin release
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The ability of leucine to stimulate insulin release was studied in an in vitro system, using microdissected pancreatic islets with a high proportion of the insulin-producing β-cells. When tested in a glucose-free medium, l-leucine stimulated insulin release over a wide concentration range with maximum effect at about 20 mm. The stimulation of insulin release was additive to that elicited by 10 mm glucose. The l-configuration was essential for leucine to be recognized by the β-cells as an insulin secretagogue. l-isoleucine, alone or in combination with l-leucine, did not affect insulin release. It seems, therefore, unlikely that all sites for l-leucine transport are identical with receptor sites for stimulation of insulin release.
Ämnesklassifikation (UKÄ) – OBLIGATORISK
|Tidskrift||Hormone Research in Paediatrics|
|Status||Published - 1972 jan 1|
|Peer review utförd||Ja|