Spermidine/spermine-N1-acetyltransferase activity in isoprenaline-stimulated rat salivary glands

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Abstract

In parotid, sublingual and submaxillary glands stimulated by continuous intravenous infusion of isoprenaline at various doses for 3 h, the concentrations of the polyamines putrescine, spermidine, spermine and N1-acetylspermidine as well as the activities of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase were determined. Ornithine decarboxylase is the enzyme that catalyses the formation of putrescine from ornithine. The most striking effect was observed in parotid glands. Here, the beta-adrenergic agonist increased the activity of spermidine/spermine-N1-acetyltransferase markedly, but only slightly (if at all) that of ornithine decarboxylase. It also increased the concentrations of N1-acetylspermidine and putrescine markedly. The result obtained in this gland indicates interconversion of higher polyamines to putrescine.

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Originalspråkengelska
Sidor (från-till)249-54
Antal sidor6
TidskriftActa Physiologica Scandinavica
Volym135
Utgåva nummer3
StatusPublished - 1989 mar
PublikationskategoriForskning
Peer review utfördJa