Spontaneous formation of vesicles and dispersed cubic and hexagonal particles in amino acid-based catanionic surfactant systems

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Spontaneous formation of vesicles and dispersed cubic and hexagonal particles in amino acid-based catanionic surfactant systems. / Rosa, Monica; Infante, MR; Miguel, MD; Lindman, Björn.

I: Langmuir, Vol. 22, Nr. 13, 2006, s. 5588-5596.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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T1 - Spontaneous formation of vesicles and dispersed cubic and hexagonal particles in amino acid-based catanionic surfactant systems

AU - Rosa, Monica

AU - Infante, MR

AU - Miguel, MD

AU - Lindman, Björn

PY - 2006

Y1 - 2006

N2 - Mixed catanionic surfactant systems based on amino acids were investigated with respect to the formation of liquid crystal dispersions and the stability of the dispersions. The surfactants used were arginine-N-lauroyl amide dihydrochloride ( ALA) and NR-lauroyl-arginine-methyl ester hydrochloride ( LAM), which are arginine-based cationic surfactants; sodium hydrogenated tallow glutamate ( HS), a glutamic-based anionic surfactant; and the anionic surfactants sodium octyl sulfate ( SOS) and sodium cetyl sulfate ( SCS). It is demonstrated that in certain ranges of composition there is a spontaneous formation of vesicular, cubic, and hexagonal structures. The solutions were characterized with respect to internal structure and size by cryogenic transmission electron microscopy ( cryo-TEM), dynamic light scattering ( DLS), and turbidity measurements. Vesicles formed spontaneously and were found for all systems studied; their size distribution is presented for the systems ALA/SCS/W and ALA/SOS/W; they are all markedly polydisperse. The aging process for the system ALA/SOS/W was monitored both by turbidity and by cryo-TEM imaging; the size distribution profile for the system becomes narrower and the number average radius decreases with time. The presence of dispersed particles with internal cubic structure ( cubosomes) and internal hexagonal structure ( hexosomes) was documented for the systems containing ALA and HS. The particles formed spontaneously and remained stably dispersed in solution; no stabilizer was required. ( Cubosome and hexosome are USPTO registered trademarks of Camurus AB, Sweden.) The spontaneous formation of particles and their stability, together with favorable biological responses, suggests a number of applications.

AB - Mixed catanionic surfactant systems based on amino acids were investigated with respect to the formation of liquid crystal dispersions and the stability of the dispersions. The surfactants used were arginine-N-lauroyl amide dihydrochloride ( ALA) and NR-lauroyl-arginine-methyl ester hydrochloride ( LAM), which are arginine-based cationic surfactants; sodium hydrogenated tallow glutamate ( HS), a glutamic-based anionic surfactant; and the anionic surfactants sodium octyl sulfate ( SOS) and sodium cetyl sulfate ( SCS). It is demonstrated that in certain ranges of composition there is a spontaneous formation of vesicular, cubic, and hexagonal structures. The solutions were characterized with respect to internal structure and size by cryogenic transmission electron microscopy ( cryo-TEM), dynamic light scattering ( DLS), and turbidity measurements. Vesicles formed spontaneously and were found for all systems studied; their size distribution is presented for the systems ALA/SCS/W and ALA/SOS/W; they are all markedly polydisperse. The aging process for the system ALA/SOS/W was monitored both by turbidity and by cryo-TEM imaging; the size distribution profile for the system becomes narrower and the number average radius decreases with time. The presence of dispersed particles with internal cubic structure ( cubosomes) and internal hexagonal structure ( hexosomes) was documented for the systems containing ALA and HS. The particles formed spontaneously and remained stably dispersed in solution; no stabilizer was required. ( Cubosome and hexosome are USPTO registered trademarks of Camurus AB, Sweden.) The spontaneous formation of particles and their stability, together with favorable biological responses, suggests a number of applications.

U2 - 10.1021/la053464p

DO - 10.1021/la053464p

M3 - Article

VL - 22

SP - 5588

EP - 5596

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 13

ER -