STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer. / Pena, Cristina; Virtudes Cespedes, Maria; Lindh, Maja Bradic; Kiflemariam, Sara; Mezheyeuski, Artur; Edqvist, Per-Henrik; Hagglof, Christina; Birgisson, Helgi; Bojmar, Linda; Jirström, Karin; Sandstrom, Per; Olsson, Eleonor; Veerla, Srinivas; Gallardo, Alberto; Sjoblom, Tobias; Chang, Andy C. -M.; Reddel, Roger R.; Mangues, Ramon; Augsten, Martin; Ostman, Arne.

I: Cancer Research, Vol. 74, Nr. 4, 2013, s. 1287-1297.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Pena, C, Virtudes Cespedes, M, Lindh, MB, Kiflemariam, S, Mezheyeuski, A, Edqvist, P-H, Hagglof, C, Birgisson, H, Bojmar, L, Jirström, K, Sandstrom, P, Olsson, E, Veerla, S, Gallardo, A, Sjoblom, T, Chang, AC-M, Reddel, RR, Mangues, R, Augsten, M & Ostman, A 2013, 'STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer', Cancer Research, vol. 74, nr. 4, s. 1287-1297. https://doi.org/10.1158/0008-5472.CAN-12-1875

APA

Pena, C., Virtudes Cespedes, M., Lindh, M. B., Kiflemariam, S., Mezheyeuski, A., Edqvist, P-H., ... Ostman, A. (2013). STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer. Cancer Research, 74(4), 1287-1297. https://doi.org/10.1158/0008-5472.CAN-12-1875

CBE

Pena C, Virtudes Cespedes M, Lindh MB, Kiflemariam S, Mezheyeuski A, Edqvist P-H, Hagglof C, Birgisson H, Bojmar L, Jirström K, Sandstrom P, Olsson E, Veerla S, Gallardo A, Sjoblom T, Chang AC-M, Reddel RR, Mangues R, Augsten M, Ostman A. 2013. STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer. Cancer Research. 74(4):1287-1297. https://doi.org/10.1158/0008-5472.CAN-12-1875

MLA

Vancouver

Pena C, Virtudes Cespedes M, Lindh MB, Kiflemariam S, Mezheyeuski A, Edqvist P-H et al. STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer. Cancer Research. 2013;74(4):1287-1297. https://doi.org/10.1158/0008-5472.CAN-12-1875

Author

Pena, Cristina ; Virtudes Cespedes, Maria ; Lindh, Maja Bradic ; Kiflemariam, Sara ; Mezheyeuski, Artur ; Edqvist, Per-Henrik ; Hagglof, Christina ; Birgisson, Helgi ; Bojmar, Linda ; Jirström, Karin ; Sandstrom, Per ; Olsson, Eleonor ; Veerla, Srinivas ; Gallardo, Alberto ; Sjoblom, Tobias ; Chang, Andy C. -M. ; Reddel, Roger R. ; Mangues, Ramon ; Augsten, Martin ; Ostman, Arne. / STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer. I: Cancer Research. 2013 ; Vol. 74, Nr. 4. s. 1287-1297.

RIS

TY - JOUR

T1 - STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

AU - Pena, Cristina

AU - Virtudes Cespedes, Maria

AU - Lindh, Maja Bradic

AU - Kiflemariam, Sara

AU - Mezheyeuski, Artur

AU - Edqvist, Per-Henrik

AU - Hagglof, Christina

AU - Birgisson, Helgi

AU - Bojmar, Linda

AU - Jirström, Karin

AU - Sandstrom, Per

AU - Olsson, Eleonor

AU - Veerla, Srinivas

AU - Gallardo, Alberto

AU - Sjoblom, Tobias

AU - Chang, Andy C. -M.

AU - Reddel, Roger R.

AU - Mangues, Ramon

AU - Augsten, Martin

AU - Ostman, Arne

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000)

PY - 2013

Y1 - 2013

N2 - Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression of PDGF receptors on stromal CAFs is associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification of the secreted glycoprotein stanniocalcin-1 (STC1) as a mediator of metastasis by PDGF receptor function in the setting of colorectal cancer. PDGF-stimulated fibroblasts increased migration and invasion of cocultured colorectal cancer cells in an STC1-dependent manner. Analyses of human colorectal cancers revealed significant associations between stromal PDGF receptor and STC1 expression. In an orthotopic mouse model of colorectal cancer, tumors formed in the presence of STC1-deficient fibroblasts displayed reduced intravasation of tumor cells along with fewer and smaller distant metastases formed. Our results reveal a mechanistic basis for understanding the contribution of PDGF-activated CAFs to cancer metastasis. Cancer Res; 73(4); 1287-97. (C) 2012 AACR.

AB - Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression of PDGF receptors on stromal CAFs is associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification of the secreted glycoprotein stanniocalcin-1 (STC1) as a mediator of metastasis by PDGF receptor function in the setting of colorectal cancer. PDGF-stimulated fibroblasts increased migration and invasion of cocultured colorectal cancer cells in an STC1-dependent manner. Analyses of human colorectal cancers revealed significant associations between stromal PDGF receptor and STC1 expression. In an orthotopic mouse model of colorectal cancer, tumors formed in the presence of STC1-deficient fibroblasts displayed reduced intravasation of tumor cells along with fewer and smaller distant metastases formed. Our results reveal a mechanistic basis for understanding the contribution of PDGF-activated CAFs to cancer metastasis. Cancer Res; 73(4); 1287-97. (C) 2012 AACR.

U2 - 10.1158/0008-5472.CAN-12-1875

DO - 10.1158/0008-5472.CAN-12-1875

M3 - Article

VL - 74

SP - 1287

EP - 1297

JO - Cancer research. Supplement

T2 - Cancer research. Supplement

JF - Cancer research. Supplement

SN - 1538-7445

IS - 4

ER -