Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

AQP7 is an important glycerol channel in human adipocytes, and its dysfunction is linked to metabolic disorders. The high-resolution X-ray structures of AQP7 unravels the molecular details of how glycerol travels through the channel and provide a structural basis for development of small-molecule drugs for targeting AQP7.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Max Planck Institute for Biophysical Chemistry
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Strukturbiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)215-222.e3
TidskriftStructure
Volym28
Utgåva nummer2
StatusPublished - 2020 feb 4
PublikationskategoriForskning
Peer review utfördJa