Structure and Function of Cu(I)- and Zn(II)-ATPases

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Copper and zinc are micronutrients essential for the function of many enzymes while also being toxic at elevated concentrations. Cu(I)- and Zn(II)-transporting P-type ATPases of subclass 1B are of key importance for the homeostasis of these transition metals, allowing ion transport across cellular membranes at the expense of ATP. Recent biochemical studies and crystal structures have significantly improved our understanding of the transport mechanisms of these proteins, but many details about their structure and function remain elusive. Here we compare the Cu(I)- and Zn(II)-ATPases, scrutinizing the molecular differences that allow transport of these two distinct metal types, and discuss possible future directions of research in the field.

Detaljer

Författare
  • Oleg Sitsel
  • Christina Gronberg
  • Henriette Elisabeth Autzen
  • Kaituo Wang
  • Gabriele Meloni
  • Poul Nissen
  • Pontus Gourdon
Enheter & grupper
Externa organisationer
  • University of Copenhagen
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Strukturbiologi
  • Biokemi och molekylärbiologi
Originalspråkengelska
Sidor (från-till)5673-5683
TidskriftBiochemistry
Volym54
Utgivningsnummer37
StatusPublished - 2015
PublikationskategoriForskning
Peer review utfördJa