Study protocol: Differential effects of diet and physical activity based interventions in pregnancy on maternal and fetal outcomes: Individual patient data (IPD) meta-analysis and health economic evaluation

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Pregnant women who gain excess weight are at risk of complications during pregnancy and in the long term. Interventions based on diet and physical activity minimise gestational weight gain with varied effect on clinical outcomes. The effect of interventions on varied groups of women based on body mass index, age, ethnicity, socioeconomic status, parity, and underlying medical conditions is not clear. Our individual patient data (IPD) meta-analysis of randomised trials will assess the differential effect of diet- and physical activity-based interventions on maternal weight gain and pregnancy outcomes in clinically relevant subgroups of women.

Randomised trials on diet and physical activity in pregnancy will be identified by searching the following databases: MEDLINE, EMBASE, BIOSIS, LILACS, Pascal, Science Citation Index, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects, and Health Technology Assessment Database. Primary researchers of the identified trials are invited to join the International Weight Management in Pregnancy Collaborative Network and share their individual patient data. We will reanalyse each study separately and confirm the findings with the original authors. Then, for each intervention type and outcome, we will perform as appropriate either a one-step or a two-step IPD meta-analysis to obtain summary estimates of effects and 95% confidence intervals, for all women combined and for each subgroup of interest. The primary outcomes are gestational weight gain and composite adverse maternal and fetal outcomes. The difference in effects between subgroups will be estimated and between-study heterogeneity suitably quantified and explored. The potential for publication bias and availability bias in the IPD obtained will be investigated. We will conduct a model-based economic evaluation to assess the cost effectiveness of the interventions to manage weight gain in pregnancy and undertake a value of information analysis to inform future research.


  • Anneloes E Ruifrok
  • Ewelina Rogozinska
  • Mireille N M van Poppel
  • Girish Rayanagoudar
  • Sally Kerry
  • Christianne J M de Groot
  • Seon Ae Yeo
  • Emma Molyneaux
  • Ruben Barakat Carballo
  • Maria Perales
  • Annick Bogaerts
  • Jose G Cecatti
  • Fernanda Surita
  • Jodie Dodd
  • Julie Owens
  • Nermeen El Beltagy
  • Roland Devlieger
  • Helena Teede
  • Cheryce Harrison
  • Lene Haakstad
  • Och 32 andra
  • Garry X Shen
  • Alexis Shub
  • Narges Motahari
  • Janette Khoury
  • Serena Tonstad
  • Riitta Luoto
  • Tarja I Kinnunen
  • Kym Guelfi
  • Fabio Facchinetti
  • Elisabetta Petrella
  • Suzanne Phelan
  • Tânia T Scudeller
  • Kathrin Rauh
  • Hans Hauner
  • Kristina Renault
  • Linda Reme Sagedal
  • Ingvild Vistad
  • Signe Nilssen Stafne
  • Siv Mørkved
  • Kjell Åsmund Salvesen
  • Christina Vinter
  • Marcia Vitolo
  • Arne Astrup
  • Nina Rica Wium Geiker
  • Fionnuala McAuliffe
  • Lucilla Poston
  • Tracy Roberts
  • Richard D Riley
  • Arri Coomarasamy
  • Khalid S. Khan
  • Ben-Willem Mol
  • Shakila Thangaratinam
Enheter & grupper
Externa organisationer
  • Academic Medical Center
  • VU University Medical Center
  • Queen Mary University
  • King's College London
  • University Hospitals Leuven
  • Alexandria University
  • Norwegian School of Sport Sciences
  • University of Manitoba
  • University of Melbourne
  • Mazandaran University
  • Oslo university hospital
  • Institute for Health Promotion Research
  • University of Tampere
  • University of Western Australia, Crawley
  • University of Modena
  • California Polytechnic State University
  • Escola Paulista de Medicina
  • Technical University of Munich
  • Competence Centre for Nutrition (KErn)
  • University of Copenhagen
  • University of Southern Denmark
  • Sørlandet Hospital
  • Norwegian University of Science and Technology
  • St. Olav’s University Hospital
  • Federal University of Health Sciences of Porto Alegre
  • Herlev Hospital
  • University College Dublin
  • Guy's and St Thomas' NHS Foundation Trust
  • University of Birmingham
  • University of North Carolina
  • Technical University of Madrid
  • University of Campinas
  • University of Adelaide
  • Monash University
TidskriftSystematic Reviews
StatusPublished - 2014 nov 4
Peer review utfördJa