Substantial Decrease in Comorbidity 5 Years After Gastric Bypass: A Population-based Study From the Scandinavian Obesity Surgery Registry

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title = "Substantial Decrease in Comorbidity 5 Years After Gastric Bypass: A Population-based Study From the Scandinavian Obesity Surgery Registry",
abstract = "OBJECTIVE:: To evaluate effect on comorbid disease and weight loss 5 years after Roux-en-Y gastric bypass (RYGB) surgery for morbid obesity in a large nationwide cohort. BACKGROUND:: The number patients having surgical procedures to treat obesity and obesity-related disease are increasing. Yet, population-based, long-term outcome studies are few. METHODS:: Data on 26,119 individuals [75.8{\%} women, 41.0 years, and body mass index (BMI) 42.8?kg/m] undergoing primary RYGB between May 1, 2007 and June 30, 2012, were collected from 2 Swedish quality registries: Scandinavian Obesity Surgery Registry and the Prescribed Drug Registry. Weight, remission of type 2 diabetes mellitus, hypertension, dyslipidemia, depression, and sleep apnea, and changes in corresponding laboratory data were studied. Five-year follow-up was 100{\%} (9774 eligible individuals) for comorbid diseases. RESULTS:: BMI decreased from 42.8?±?5.5 to 31.2?±?5.5?kg/m at 5 years, corresponding to 27.7{\%} reduction in total body weight. Prevalence of type 2 diabetes mellitus (15.5{\%}–5.9{\%}), hypertension (29.7{\%}–19.5{\%}), dyslipidemia (14.0{\%}–6.8{\%}), and sleep apnea (9.6{\%}–2.6{\%}) was reduced. Greater weight loss was a positive prognostic factor, whereas increasing age or BMI at baseline was a negative prognostic factor for remission. The use of antidepressants increased (24.1{\%}–27.5{\%}). Laboratory status was improved, for example, fasting glucose and glycated hemoglobin decreased from 6.1 to 5.4?mmol/mol and 41.8{\%} to 37.7{\%}, respectively. CONCLUSIONS:: In this nationwide study, gastric bypass resulted in large improvements in obesity-related comorbid disease and sustained weight loss over a 5-year period. The increased use of antidepressants warrants further investigation.",
author = "Magnus Sundbom and Jakob Hedberg and Richard Marsk and Lars Boman and Ami Bylund and Jan Hedenbro and Anna Laurenius and G{\"o}ran Lundeg{\aa}rdh and Peter M{\"o}ller and Torsten Olbers and Johan Ottosson and Ingmar N{\"a}slund and Erik N{\"a}slund",
year = "2017",
doi = "10.1097/SLA.0000000000001920",
language = "English",
volume = "265",
pages = "1166--1171",
journal = "Annals of Surgery",
issn = "1528-1140",
publisher = "Lippincott Williams & Wilkins",
number = "6",