Surface activity of tear fluid in patients with primary Sjögren's syndrome.

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Surface activity of tear fluid in patients with primary Sjögren's syndrome. / Zhao, Jiang; Manthorpe, Rolf; Wollmer, Per.

I: Clinical Physiology and Functional Imaging, Vol. 22, Nr. 1, 2002, s. 24-27.

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TY - JOUR

T1 - Surface activity of tear fluid in patients with primary Sjögren's syndrome.

AU - Zhao, Jiang

AU - Manthorpe, Rolf

AU - Wollmer, Per

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Internal Medicine (013242500), Clinical Physiology (013242300), Clinical Physiology and Nuclear Medicine Unit (013242320), Department of Rheumatology (013036000)

PY - 2002

Y1 - 2002

N2 - Rupture of the preocular tear film leads to formation of a dry spot on the cornea with ocular irritation and symptoms of dry eye. One of the factors determining the stability of the tear film is its surface activity. The purpose of this study was to examine the surface activity of tear fluid from patients with Sjögren's syndrome. Tear fluid was sampled from the eyes of 16 patients with primary Sjögren's syndrome. The surface activity of the sample was measured on a Wilhelmy balance. Maximum and minimum surface tension was 72·2 ± 1·7 and 52·9 ± 7·4 mN m-1, respectively. Corresponding values in a previously studied group of normal subjects were 71·5 ± 1·3 and 46·6 ± 3·8 mN m-1, respectively. The difference in minimal surface tension was statistically significant (P<0·001). Reduced surface activity may be caused by dysfunction of the Meibomian glands and suggests a mechanism for causing the symptoms of dry eyes.

AB - Rupture of the preocular tear film leads to formation of a dry spot on the cornea with ocular irritation and symptoms of dry eye. One of the factors determining the stability of the tear film is its surface activity. The purpose of this study was to examine the surface activity of tear fluid from patients with Sjögren's syndrome. Tear fluid was sampled from the eyes of 16 patients with primary Sjögren's syndrome. The surface activity of the sample was measured on a Wilhelmy balance. Maximum and minimum surface tension was 72·2 ± 1·7 and 52·9 ± 7·4 mN m-1, respectively. Corresponding values in a previously studied group of normal subjects were 71·5 ± 1·3 and 46·6 ± 3·8 mN m-1, respectively. The difference in minimal surface tension was statistically significant (P<0·001). Reduced surface activity may be caused by dysfunction of the Meibomian glands and suggests a mechanism for causing the symptoms of dry eyes.

KW - Female

KW - Human

KW - Adolescent

KW - Adult

KW - Aged

KW - Middle Age

KW - Reference Values

KW - Sjogren's Syndrome: metabolism

KW - Support

KW - Non-U.S. Gov't

KW - Surface Tension

KW - Tears: chemistry

U2 - 10.1046/j.1475-097X.2002.00389.x

DO - 10.1046/j.1475-097X.2002.00389.x

M3 - Article

VL - 22

SP - 24

EP - 27

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

SN - 1475-0961

IS - 1

ER -