Survival in amoeba-a major selection pressure on the presence of bacterial copper and zinc resistance determinants? Identification of a "copper pathogenicity island"

Forskningsoutput: TidskriftsbidragÖversiktsartikel


The presence of metal resistance determinants in bacteria usually is attributed to geological or anthropogenic metal contamination in different environments or associated with the use of antimicrobial metals in human healthcare or in agriculture. While this is certainly true, we hypothesize that protozoan predation and macrophage killing are also responsible for selection of copper/zinc resistance genes in bacteria. In this review, we outline evidence supporting this hypothesis, as well as highlight the correlation between metal resistance and pathogenicity in bacteria. In addition, we introduce and characterize the "copper pathogenicity island" identified in Escherichia coli and Salmonella strains isolated from copper- and zinc-fed Danish pigs.


  • Xiuli Hao
  • Freja L. Luethje
  • Yanan Qin
  • Sylvia Franke McDevitt
  • Nataliya Lutay
  • Jon L. Hobman
  • Karishma Asiani
  • Fernando C. Soncini
  • Nadezhda German
  • Siyu Zhang
  • Yong-Guan Zhu
  • Christopher Rensing
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Mikrobiologi inom det medicinska området


Sidor (från-till)5817-5824
TidskriftApplied Microbiology and Biotechnology
Utgåva nummer14
StatusPublished - 2015
Peer review utfördJa