Synaptic vesicle protein 2A as a potential biomarker in synaptopathies

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Measuring synaptic density in vivo using positron emission tomography (PET) imaging-based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much attention recently due to its potential research and clinical applications in synaptopathies, including neurodegenerative and psychiatric diseases. Fluid-based biomarkers in proteinopathies have previously been suggested to provide information on pathology and disease status that is complementary to PET-based measures, and the same can be hypothesized with respect to SV2A. This review provides an overview of the current state of SV2A PET imaging as a biomarker of synaptic density, the potential role of fluid-based biomarkers for SV2A, and related future perspectives.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Sahlgrenska Academy
  • King's College London
  • Göteborgs universitet
  • Federal University of Rio Grande do Sul
  • Pontifical Catholic University of Rio Grande do Sul
  • Sahlgrenska University Hospital
  • University College London
  • Uppsala universitet, Historiska institutionen
  • Uppsala University Hospital
  • South London and Maudsley NHS Foundation Trust
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)34-42
TidskriftMolecular and Cellular Neuroscience
Volym97
Tidigt onlinedatum2019
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa