Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Bibtex

@article{634372ed967f44f5b2107b27ebb8476b,
title = "Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions.",
abstract = "OBJECTIVE: To investigate whether fragmentation of proteoglycans in arthritis results in domains that have different levels of release from cartilage at different stages of the disease.METHODS: Two regions of the proteoglycan, the hyaluronan-binding region and the glycosaminoglycan-rich region of the core protein, were measured, by immunoassay, in knee joint synovial fluids of patients with rheumatoid arthritis or reactive arthritis.RESULTS: Synovial fluid concentrations of the glycosaminoglycan-rich region were highest in rheumatoid arthritis patients who had little cartilage damage as determined by radiography, whereas release of the hyaluronan-binding region predominated in patients with advanced cartilage destruction. In reactive arthritis, release of the glycosaminoglycan-rich region predominated.CONCLUSION: These findings indicate that the hyaluronan-binding region is initially retained in the tissue during the development of cartilage destruction. The combined analysis of these markers offers a new avenue for assessment of the degree of cartilage damage in arthritis.",
keywords = "Synovial fluid, proteoglycans",
author = "Tore Saxne and Dick Heineg{\aa}rd",
year = "1992",
language = "English",
volume = "35",
pages = "385--390",
journal = "Arthritis & Rheumatology",
issn = "1529-0131",
publisher = "John Wiley & Sons",
number = "4",

}