Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions.

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Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions. / Saxne, Tore; Heinegård, Dick.

I: Arthritis and Rheumatism, Vol. 35, Nr. 4, 1992, s. 385-390.

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TY - JOUR

T1 - Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions.

AU - Saxne, Tore

AU - Heinegård, Dick

PY - 1992

Y1 - 1992

N2 - OBJECTIVE: To investigate whether fragmentation of proteoglycans in arthritis results in domains that have different levels of release from cartilage at different stages of the disease.METHODS: Two regions of the proteoglycan, the hyaluronan-binding region and the glycosaminoglycan-rich region of the core protein, were measured, by immunoassay, in knee joint synovial fluids of patients with rheumatoid arthritis or reactive arthritis.RESULTS: Synovial fluid concentrations of the glycosaminoglycan-rich region were highest in rheumatoid arthritis patients who had little cartilage damage as determined by radiography, whereas release of the hyaluronan-binding region predominated in patients with advanced cartilage destruction. In reactive arthritis, release of the glycosaminoglycan-rich region predominated.CONCLUSION: These findings indicate that the hyaluronan-binding region is initially retained in the tissue during the development of cartilage destruction. The combined analysis of these markers offers a new avenue for assessment of the degree of cartilage damage in arthritis.

AB - OBJECTIVE: To investigate whether fragmentation of proteoglycans in arthritis results in domains that have different levels of release from cartilage at different stages of the disease.METHODS: Two regions of the proteoglycan, the hyaluronan-binding region and the glycosaminoglycan-rich region of the core protein, were measured, by immunoassay, in knee joint synovial fluids of patients with rheumatoid arthritis or reactive arthritis.RESULTS: Synovial fluid concentrations of the glycosaminoglycan-rich region were highest in rheumatoid arthritis patients who had little cartilage damage as determined by radiography, whereas release of the hyaluronan-binding region predominated in patients with advanced cartilage destruction. In reactive arthritis, release of the glycosaminoglycan-rich region predominated.CONCLUSION: These findings indicate that the hyaluronan-binding region is initially retained in the tissue during the development of cartilage destruction. The combined analysis of these markers offers a new avenue for assessment of the degree of cartilage damage in arthritis.

KW - Synovial fluid

KW - proteoglycans

M3 - Article

VL - 35

SP - 385

EP - 390

JO - Arthritis & Rheumatology

JF - Arthritis & Rheumatology

SN - 1529-0131

IS - 4

ER -