Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Modification of the St. John's wort acylphloroglucinol constituent, hyperforin (1), by acylation, alkylation, and oxidation resulted in detrimental effects on the inhibition of the synaptosomal accumulation of serotonin, showing the existence of definite structure-activity relationships in this in vitro test system and highlighting the role of the enolized cyclohexanedione moiety for activity on neurotransmitter reuptake.

Detaljer

Författare
  • L Verotta
  • G Appendino
  • E Belloro
  • F Bianchi
  • Olov Sterner
  • M Lovati
  • E Bombardelli
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Organisk kemi
Originalspråkengelska
Sidor (från-till)433-438
TidskriftJournal of Natural Products
Volym65
Utgivningsnummer4
StatusPublished - 2002
PublikationskategoriForskning
Peer review utfördJa