Synthesis and structures of a pincer-type rhodium(III) complex: Reactivity toward biomolecules

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Synthesis and structures of a pincer-type rhodium(III) complex : Reactivity toward biomolecules. / Milutinović, Milan M.; Bogojeski, Jovana V.; Klisurić, Olivera; Scheurer, Andreas; Elmroth, Sofi K C; Bugarčić, Živadin D.

I: Dalton Transactions, Vol. 45, Nr. 39, 2016, s. 15481-15491.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Milutinović, MM, Bogojeski, JV, Klisurić, O, Scheurer, A, Elmroth, SKC & Bugarčić, ŽD 2016, 'Synthesis and structures of a pincer-type rhodium(III) complex: Reactivity toward biomolecules', Dalton Transactions, vol. 45, nr. 39, s. 15481-15491. https://doi.org/10.1039/c6dt02772e

APA

Milutinović, M. M., Bogojeski, J. V., Klisurić, O., Scheurer, A., Elmroth, S. K. C., & Bugarčić, Ž. D. (2016). Synthesis and structures of a pincer-type rhodium(III) complex: Reactivity toward biomolecules. Dalton Transactions, 45(39), 15481-15491. https://doi.org/10.1039/c6dt02772e

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Author

Milutinović, Milan M. ; Bogojeski, Jovana V. ; Klisurić, Olivera ; Scheurer, Andreas ; Elmroth, Sofi K C ; Bugarčić, Živadin D. / Synthesis and structures of a pincer-type rhodium(III) complex : Reactivity toward biomolecules. I: Dalton Transactions. 2016 ; Vol. 45, Nr. 39. s. 15481-15491.

RIS

TY - JOUR

T1 - Synthesis and structures of a pincer-type rhodium(III) complex

T2 - Reactivity toward biomolecules

AU - Milutinović, Milan M.

AU - Bogojeski, Jovana V.

AU - Klisurić, Olivera

AU - Scheurer, Andreas

AU - Elmroth, Sofi K C

AU - Bugarčić, Živadin D.

PY - 2016

Y1 - 2016

N2 - A novel rhodium(iii) complex [RhIII(H2LtBu)Cl3] (1) (H2LtBu = 2,6-bis(5-tert-butyl-1H-pyrazol-3-yl)pyridine) containing a pincer type, tridentate nitrogen-donor chelate system was synthesized. Single crystal X-ray structure analysis revealed that 1 crystallizes in the orthorhombic space group Pbcn with a = 20.7982(6), b = 10.8952(4), c = 10.9832(4) Å, V = 2488.80(15) Å3, and eight molecules in the unit cell. The rhodium center in the complex [RhIII(H2LtBu)Cl3] (1) is coordinated in a slightly distorted octahedral geometry by the tridentate N,N,N-donor and three chloro ligands, adopting a mer arrangement with an essentially planar ligand skeleton. Due to the tridentate coordination of the N,N,N-donor, the central nitrogen atom N1 is located closer to the RhIII center. The reactivity of the synthesized complex toward small biomolecules (l-methionine (l-Met), guanosine-5′-monophosphate (5′-GMP), l-histidine (l-His) and glutathione (GSH)) and to a series of duplex DNAs and RNA was investigated. The order of reactivity of the studied small biomolecules is: 5′-GMP > GSH > l-Met > l-His. Duplex RNA reacts faster with the [RhIII(H2LtBu)Cl3] complex than duplex DNA, while shorter duplex DNA (15mer GG) reacts faster compared with 22mer GG duplex DNA. In addition, a higher reactivity is achieved with a DNA duplex with a centrally located GG-sequence than with a 22GTG duplex DNA, in which the GG-sequence is separated by a T base. Furthermore, the interaction of this metal complex 1 with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) was examined by absorption (UV-Vis) and emission spectral studies (EthBr displacement studies). Overall, the studied complex exhibited good DNA and BSA interaction ability.

AB - A novel rhodium(iii) complex [RhIII(H2LtBu)Cl3] (1) (H2LtBu = 2,6-bis(5-tert-butyl-1H-pyrazol-3-yl)pyridine) containing a pincer type, tridentate nitrogen-donor chelate system was synthesized. Single crystal X-ray structure analysis revealed that 1 crystallizes in the orthorhombic space group Pbcn with a = 20.7982(6), b = 10.8952(4), c = 10.9832(4) Å, V = 2488.80(15) Å3, and eight molecules in the unit cell. The rhodium center in the complex [RhIII(H2LtBu)Cl3] (1) is coordinated in a slightly distorted octahedral geometry by the tridentate N,N,N-donor and three chloro ligands, adopting a mer arrangement with an essentially planar ligand skeleton. Due to the tridentate coordination of the N,N,N-donor, the central nitrogen atom N1 is located closer to the RhIII center. The reactivity of the synthesized complex toward small biomolecules (l-methionine (l-Met), guanosine-5′-monophosphate (5′-GMP), l-histidine (l-His) and glutathione (GSH)) and to a series of duplex DNAs and RNA was investigated. The order of reactivity of the studied small biomolecules is: 5′-GMP > GSH > l-Met > l-His. Duplex RNA reacts faster with the [RhIII(H2LtBu)Cl3] complex than duplex DNA, while shorter duplex DNA (15mer GG) reacts faster compared with 22mer GG duplex DNA. In addition, a higher reactivity is achieved with a DNA duplex with a centrally located GG-sequence than with a 22GTG duplex DNA, in which the GG-sequence is separated by a T base. Furthermore, the interaction of this metal complex 1 with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) was examined by absorption (UV-Vis) and emission spectral studies (EthBr displacement studies). Overall, the studied complex exhibited good DNA and BSA interaction ability.

UR - http://www.scopus.com/inward/record.url?scp=84990050490&partnerID=8YFLogxK

U2 - 10.1039/c6dt02772e

DO - 10.1039/c6dt02772e

M3 - Article

C2 - 27722449

AN - SCOPUS:84990050490

VL - 45

SP - 15481

EP - 15491

JO - Dalton Transactions

JF - Dalton Transactions

SN - 1477-9234

IS - 39

ER -