Synthesis of Fused Tertazole- and Imidazole Derivatives via Iodocyclization.
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Abstract
The possibility to prepare fused tetrazole- and imidazole derivatives by iodocyclization in moderate to excellent yields is demonstrated. In some examples the cyclizations were not following Baldwin's rules entirely, i.e. exo-selectivity. Nucleophilic substitution of the formed iodides gave different results depending on the hardness of the nucleophile. Thus, elimination of the iodide could be a problem but a substitution reaction with ethyl potassium xanthate and a radical reaction using acrylonitrile were tolerated. In addition, we showed that it is possible to selectively use three iodo substituents individually in one of the fused imidazole derivatives.
Detaljer
Författare | |
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Enheter & grupper | |
Forskningsområden | Ämnesklassifikation (UKÄ) – OBLIGATORISK
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Originalspråk | engelska |
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Sidor (från-till) | 6759-6769 |
Tidskrift | Tetrahedron |
Volym | 59 |
Utgåva nummer | 35 |
Status | Published - 2003 |
Publikationskategori | Forskning |
Peer review utförd | Ja |