Systematic review of cost-effectiveness of myocardial perfusion scintigraphy in patients with ischaemic heart disease A report from the cardiovascular committee of the European Association of Nuclear Medicine. Endorsed by the European Association of Cardiovascular Imaging

Forskningsoutput: TidskriftsbidragÖversiktsartikel


Coronary artery disease (CAD) is a major cause of death and disability. Several diagnostic tests, such as myocardial perfusion scintigraphy (MPS), are accurate for the detection of CAD, as well as having prognostic value for the prediction of cardiovascular events. Nevertheless, the diagnostic and prognostic value of these tests should be cost-effective and should lead to improved clinical outcome. We have reviewed the literature on the cost-effectiveness of MPS in different circumstances: (i) the diagnosis and management of CAD; (ii) comparison with exercise electrocardiography (ECG) and other imaging tests; (iii) as gatekeeper to invasive coronary angiography (ICA), (iv) the impact of appropriate use criteria; (v) acute chest pain, and (vi) screening of asymptomatic patients with type-2 diabetes. In total 57 reports were included. Although most non-invasive imaging tests are cost-effective compared with alternatives, the data conflict on which non-invasive strategy is the most cost-effective. Different definitions of cost-effectiveness further confound the subject. Computer simulations of clinical diagnosis and management are influenced by the assumptions made. For instance, diagnostic accuracy is often defined against an anatomical standard that is wrongly assumed to be perfect. Conflicting data arise most commonly from these incorrect or differing assumptions.


  • Elin Trägårdh
  • Siok Swan Tan
  • Jan Bucerius
  • Alessia Gimelli
  • Oliver Gaemperli
  • Oliver Lindner
  • Denis Agostini
  • Christopher Ubleis
  • Roberto Sciagra
  • Riemer H. Slart
  • S. Richard Underwood
  • Fabien Hyafil
  • Marcus Hacker
  • Hein J. Verberne
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
  • Erasmus University Rotterdam
  • Maastricht University
  • Universitätsklinikum der RWTH Aachen
  • Ludwig-Maximilian University of Munich
  • University of Florence
  • University Medical Center Groningen
  • Royal Cornwall Hospital
  • Hopital Bichat-Claude-Bernard AP-HP
  • Medical University of Vienna
  • Academic Medical Center
  • Tuscany Gabriele Monasterio Foundation
  • University Hospital of Zurich
  • Ruhr-University Bochum
  • University of Caen Normandy
  • Imperial College London

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicinsk laboratorie- och mätteknik


Sidor (från-till)825-832
Antal sidor8
TidskriftEuropean Heart Journal Cardiovascular Imaging
Utgåva nummer8
StatusPublished - 2017 aug 1
Peer review utfördJa