T-cell and B-cell perturbations are similar in ART-naive HIV-1 and HIV-1/2 dually infected patients

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

BACKGROUND: HIV-2 may slow progression of a subsequently acquired HIV-1 infection through cross-neutralizing antibodies and polyfunctional CD8 T cells. We hypothesized that HIV-1/2 dually infected patients compared with HIV-1-infected patients had more preserved immune maturation subsets and less immune activation of T and B cells. METHODS: ART-naive patients with HIV-1 (n = 83) or HIV-1/2 dual (n = 27) infections were included in this cross-sectional study at an HIV clinic in Guinea-Bissau. Peripheral blood mononuclear cells (PBMCs) were analyzed by flow cytometry according to T-cell maturation and activation, regulatory T-cell fraction, and B-cell maturation and activation. RESULTS: HIV-1/2 dually infected patients had lower levels of HIV-1 RNA compared with patients with HIV-1 infection, but the levels of total HIV RNA (HIV-1 and HIV-2) were similar in the two patient groups. T-cell maturation, and proportions of regulatory T cells (FoxP3+) were also similar in the two groups. HIV-1/2 dually infected patients had higher proportions of CD4 and CD8 T cells positive for the activation marker CD38, but there was no difference in other T-cell activation markers (CD28, CTLA-4, PD-1). HIV-1/2 dually infected patients also had higher proportions of IgM-only B cells and plasmablasts. CONCLUSION: HIV-1/2 was not associated with less immune perturbations than for HIV-1 infection.

Detaljer

Författare
  • Bissau HIV Cohort study group
  • Bo L. Hønge
  • Mikkel S. Petersen
  • Sanne Jespersen
  • Candida Medina
  • David D.S. Té
  • Bertram Kjerulff
  • Mads M. Jensen
  • Ditte Steiniche
  • Joakim Esbjörnsson
  • Alex L. Laursen
  • Christian Wejse
  • Henrik Krarup
  • Bjarne K. Møller
  • Christian Erikstrup
Enheter & grupper
Externa organisationer
  • Bandim Health Project, Indepth Network
  • Aarhus University Hospital
  • University of Oxford
  • Aarhus University
  • Aalborg University
  • Ministry of Health, Guinea-Bissau
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Infektionsmedicin
Originalspråkengelska
Sidor (från-till)1143-1153
Antal sidor11
TidskriftAIDS (London, England)
Volym33
Utgivningsnummer7
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa