T-cell recruitment to the intestinal mucosa.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


title = "T-cell recruitment to the intestinal mucosa.",
abstract = "The intestinal epithelium and underlying lamina propria contains large numbers of T cells that play an important role in maintaining intestinal homeostasis and defense against intestinal pathogens. Recent years have seen several significant advances in our understanding of the mechanisms regulating T-cell localization to the intestinal mucosa. For instance, we now know that the small intestine 'imprints' gut homing properties on T cells by inducing the expression of specific integrins and chemokine receptors. Further studies have identified distinct subsets of intestinal dendritic cells that use retinoic acid to generate both gut-tropic and regulatory T cells. As our understanding of the mechanisms regulating the generation of gut tropic T-cell populations evolves, the possibility of targeting these processes for mucosal vaccine development and treatment of intestinal immune pathology become more apparent.",
author = "William Agace",
year = "2008",
doi = "10.1016/j.it.2008.08.003",
language = "English",
volume = "Oct 4.",
pages = "514--522",
journal = "Trends in Immunology",
issn = "1471-4981",
publisher = "Elsevier",