T-cell recruitment to the intestinal mucosa.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

T-cell recruitment to the intestinal mucosa. / Agace, William.

I: Trends in Immunology, Vol. Oct 4., 2008, s. 514-522.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

APA

CBE

MLA

Vancouver

Author

RIS

TY - JOUR

T1 - T-cell recruitment to the intestinal mucosa.

AU - Agace, William

PY - 2008

Y1 - 2008

N2 - The intestinal epithelium and underlying lamina propria contains large numbers of T cells that play an important role in maintaining intestinal homeostasis and defense against intestinal pathogens. Recent years have seen several significant advances in our understanding of the mechanisms regulating T-cell localization to the intestinal mucosa. For instance, we now know that the small intestine 'imprints' gut homing properties on T cells by inducing the expression of specific integrins and chemokine receptors. Further studies have identified distinct subsets of intestinal dendritic cells that use retinoic acid to generate both gut-tropic and regulatory T cells. As our understanding of the mechanisms regulating the generation of gut tropic T-cell populations evolves, the possibility of targeting these processes for mucosal vaccine development and treatment of intestinal immune pathology become more apparent.

AB - The intestinal epithelium and underlying lamina propria contains large numbers of T cells that play an important role in maintaining intestinal homeostasis and defense against intestinal pathogens. Recent years have seen several significant advances in our understanding of the mechanisms regulating T-cell localization to the intestinal mucosa. For instance, we now know that the small intestine 'imprints' gut homing properties on T cells by inducing the expression of specific integrins and chemokine receptors. Further studies have identified distinct subsets of intestinal dendritic cells that use retinoic acid to generate both gut-tropic and regulatory T cells. As our understanding of the mechanisms regulating the generation of gut tropic T-cell populations evolves, the possibility of targeting these processes for mucosal vaccine development and treatment of intestinal immune pathology become more apparent.

U2 - 10.1016/j.it.2008.08.003

DO - 10.1016/j.it.2008.08.003

M3 - Article

VL - Oct 4.

SP - 514

EP - 522

JO - Trends in Immunology

T2 - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4981

ER -