Temporal trend of autonomic nerve function and HSP27, MIF and PAI-1 in type 1 diabetes

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Aim: Diabetes mellitus type 1 (T1D) has numerous complications including autonomic neuropathy, i.e. dysfunction of the autonomous nervous system. This study focuses on Heat Shock Protein 27 (HSP27), Macrophage Migration Inhibitory Factor (MIF), Plasminogen Activator Inhibitor-1 (PAI-1) and HbA1c and their possible roles in effects of diabetes on the autonomic nervous system.
Methods: Patients with T1D (n = 32, 41% women) were recruited in 1985 and followed up on four occasions (1989, 1993, 1998, and 2005). Autonomic function was tested using expiration/inspiration (E/I-ratio). Blood samples, i.e. HSP27 (last three occasions), MIF, PAI-1 (last two occasions) and HbA1c (five occasions), were analyzed.
Results: Autonomic nerve function deteriorated over time during the 20-year-period, but levels of HSP27, MIF, and PAI-1 were not associated with cardiovascular autonomic neuropathy. MIF and PAI-1 were lower in T1D than in healthy controls in 2005. Increased HbA1c correlated with a decrease in E/I-ratio.
Conclusions: Neither the neuroprotective substance HSP27 nor the inflammatory substances, MIF and PAI-1 were associated with measures of cardiovascular autonomic nerve function, but a deterioration of such function was observed in relation to increasing HbA1c in T1D during a 20-year follow-up period.
Improved glucose control might be associated with protection against autonomic neuropathy in T1D.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
  • Umeå University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Endokrinologi och diabetes

Nyckelord

  • diabetes, autonom neuropati, HSP27, MIF, PAI-1, HbA1c
Originalspråkengelska
Sidor (från-till)15-21
TidskriftJournal of Clinical and Translational Endocrinology
Volym8
StatusPublished - 2017 jun
PublikationskategoriForskning
Peer review utfördJa

Relaterad forskningsoutput

Malin Zimmerman, 2018, Lund: Lund University, Faculty of Medicine. 100 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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