The 5-hydroxytryptamine stimulated formation of inositol phosphate is inhibited in platelets from alcoholics

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Bibtex

@article{8099d7caec104b078e8f05b9c5f3a26f,
title = "The 5-hydroxytryptamine stimulated formation of inositol phosphate is inhibited in platelets from alcoholics",
abstract = "The accumulation of inositol monophosphate (IP1) was measured after stimulation of 5-hydroxytryptamine2 (5-HT2) receptors on platelets from alcoholics and healthy controls. In controls, 5-HT induced a dose-dependent response with an EC50 = 2 x 10(-6) M and a maximal response at 10(-5) M. Ritanserin, a selective 5-HT2 antagonist, markedly reduced the accumulation. The IP1 formation after stimulation by 10(-5) M 5-HT was significantly impaired in platelets from alcoholics as compared to controls. This study indicates that the 5-HT2 receptor function is inhibited in alcoholics. It also illustrates the possibility of using IP1 formation in peripheral cells as a mean of studying receptor function in disease.",
author = "Per Simonsson and Christer Alling",
year = "1988",
doi = "10.1016/0024-3205(88)90076-8",
language = "English",
volume = "42",
pages = "385--391",
journal = "Life Sciences",
issn = "1879-0631",
publisher = "Elsevier",
number = "4",

}