The 5-hydroxytryptamine stimulated formation of inositol phosphate is inhibited in platelets from alcoholics

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The 5-hydroxytryptamine stimulated formation of inositol phosphate is inhibited in platelets from alcoholics. / Simonsson, Per; Alling, Christer.

I: Life Sciences, Vol. 42, Nr. 4, 1988, s. 385-391.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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T1 - The 5-hydroxytryptamine stimulated formation of inositol phosphate is inhibited in platelets from alcoholics

AU - Simonsson, Per

AU - Alling, Christer

PY - 1988

Y1 - 1988

N2 - The accumulation of inositol monophosphate (IP1) was measured after stimulation of 5-hydroxytryptamine2 (5-HT2) receptors on platelets from alcoholics and healthy controls. In controls, 5-HT induced a dose-dependent response with an EC50 = 2 x 10(-6) M and a maximal response at 10(-5) M. Ritanserin, a selective 5-HT2 antagonist, markedly reduced the accumulation. The IP1 formation after stimulation by 10(-5) M 5-HT was significantly impaired in platelets from alcoholics as compared to controls. This study indicates that the 5-HT2 receptor function is inhibited in alcoholics. It also illustrates the possibility of using IP1 formation in peripheral cells as a mean of studying receptor function in disease.

AB - The accumulation of inositol monophosphate (IP1) was measured after stimulation of 5-hydroxytryptamine2 (5-HT2) receptors on platelets from alcoholics and healthy controls. In controls, 5-HT induced a dose-dependent response with an EC50 = 2 x 10(-6) M and a maximal response at 10(-5) M. Ritanserin, a selective 5-HT2 antagonist, markedly reduced the accumulation. The IP1 formation after stimulation by 10(-5) M 5-HT was significantly impaired in platelets from alcoholics as compared to controls. This study indicates that the 5-HT2 receptor function is inhibited in alcoholics. It also illustrates the possibility of using IP1 formation in peripheral cells as a mean of studying receptor function in disease.

U2 - 10.1016/0024-3205(88)90076-8

DO - 10.1016/0024-3205(88)90076-8

M3 - Article

VL - 42

SP - 385

EP - 391

JO - Life Sciences

JF - Life Sciences

SN - 1879-0631

IS - 4

ER -