The anandamide transport inhibitor AM404 activates vanilloid receptors

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The possibility that the anandamide transport inhibitor N-(4-hydroxyphenyl)-5,8,11,14-eicosatetraenamide (AM404), structurally similar to the vanilloid receptor agonists anandamide and capsaicin, may also activate vanilloid receptors and cause vasodilation was examined. AM404 evoked concentration-dependent relaxations in segments of rat isolated hepatic artery contracted with phenylephrine. Relaxations were abolished in preparations pre-treated with capsaicin. The calcitonin-gene related peptide (CGRP) receptor antagonist CGRP-(8-37) also abolished relaxations. The vanilloid receptor antagonist capsazepine inhibited vasodilation by AM404 and blocked AM404-induced currents in patch-clamp experiments on Xenopus oocytes expressing the vanilloid subtype 1 receptor (VR1). In conclusion, AM404 activates native and cloned vanilloid receptors. Copyright (C) 2000 Elsevier Science B.V.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • University of California, San Francisco
  • Lund University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Farmaceutisk vetenskap

Nyckelord

Originalspråkengelska
Sidor (från-till)39-42
Antal sidor4
TidskriftEuropean Journal of Pharmacology
Volym396
Utgivningsnummer1
StatusPublished - 2000 maj 12
PublikationskategoriForskning
Peer review utfördJa