The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11 108 case patients and 13 933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.

Detaljer

Författare
  • Mark M. Iles
  • D. Timothy Bishop
  • John C. Taylor
  • Nicholas K. Hayward
  • Myriam Brossard
  • Anne E. Cust
  • Alison M. Dunning
  • Jeffrey E. Lee
  • Eric K. Moses
  • Lars A. Akslen
  • Per A. Andresen
  • Marie-Francoise Avril
  • Esther Azizi
  • Giovanna Bianchi Scarra
  • Kevin M. Brown
  • Tadeusz Debniak
  • David E. Elder
  • Eitan Friedman
  • Paola Ghiorzo
  • Elizabeth M. Gillanders
  • Alisa M. Goldstein
  • Nelleke A. Gruis
  • Johan Hansson
  • Mark Harland
  • Per Helsing
  • Marko Hocevar
  • Veronica Hoiom
  • Peter A. Kanetsky
  • Maria Teresa Landi
  • Julie Lang
  • G. Mark Lathrop
  • Jan Lubinski
  • Rona M. Mackie
  • Nicholas G. Martin
  • Anders Molven
  • Grant W. Montgomery
  • Srdjan Novakovic
  • Susana Puig
  • Joan Anton Puig-Butille
  • Graham L. Radford-Smith
  • Juliette Randerson-Moor
  • Nienke van der Stoep
  • Remco van Doorn
  • David C. Whiteman
  • Stuart MacGregor
  • Karen A. Pooley
  • Sarah V. Ward
  • Graham J. Mann
  • Christopher I. Amos
  • Paul D. P. Pharoah
  • Florence Demenais
  • Matthew H. Law
  • Julia A. Newton Bishop
  • Jennifer H. Barrett
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
Originalspråkengelska
Sidor (från-till)dju267
TidskriftJournal of the National Cancer Institute
Volym106
Utgåva nummer10
StatusPublished - 2014
PublikationskategoriForskning
Peer review utfördJa