The effects of trifluoperazine on fast and slow axonal transport in the rabbit vagus nerve

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The effects of trifluoperazine (TFP) on fast and slow axonal transport (AXT) of labeled proteins were examined in the rabbit vagus nerve. Cuffs soaked in a 10 mM, but not 0.1 mM or 1 mM, concentration of TFP applied locally around the vagus nerve in vivo blocked both fast and slow AXT, as measured by the accumulation of 3H‐labeled proteins. In vitro, fast AXT was affected by 0.1 mM TFP. The TFP cuff treatment caused a reduction in the number of axonal microtubules (MT) whereas cuffs soaked in saline had no effect. The levels of ATP, ADP, and AMP were not significantly lowered by the TFP treatment. The results suggest that both fast and slow AXT are sensitive to TFP treatment, and that the axonal MT‐system may be the main target of the drug.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • University of Liverpool
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cellbiologi
Originalspråkengelska
Sidor (från-till)283-293
Antal sidor11
TidskriftJournal of Neurobiology
Volym18
Utgåva nummer3
StatusPublished - 1987
PublikationskategoriForskning
Peer review utfördJa