The Emerging Role of Calcium-activated Chloride Channel Regulator 1 in Cancer

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Calcium-activated chloride channel regulator 1 (CLCA1) belongs to a group of secreted self-cleaving proteins, which activate calcium-dependent chloride channels. CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma. Recently, additional functions of CLCA1 have been unveiled, including its metalloprotease property and involvement in mucus homeostasis and immune modulation. Emerging evidence suggests that CLCA1 may also be involved in the pathophysiology of colorectal, pancreatic and ovarian cancer. There is growing interest in utilizing CLCA1 as a diagnostic, prognostic and predictive biomarker, as well as a potential therapeutic target. In this review, the functional role of CLCA1, with a particular focus on cancer, is described.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • The 2nd Affiliated Hospital & Yuying Children's Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi

Nyckelord

Originalspråkengelska
Sidor (från-till)1661-1666
Antal sidor6
TidskriftAnticancer research
Volym39
Utgåva nummer4
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa