The executioners sing a new song: killer caspases activate microglia

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The executioners sing a new song: killer caspases activate microglia. / Venero, J. L.; Burguillos Garcia, Miguel; Brundin, Patrik; Joseph, B.

I: Cell Death and Differentiation, Vol. 18, Nr. 11, 2011, s. 1679-1691.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Harvard

Venero, JL, Burguillos Garcia, M, Brundin, P & Joseph, B 2011, 'The executioners sing a new song: killer caspases activate microglia', Cell Death and Differentiation, vol. 18, nr. 11, s. 1679-1691. https://doi.org/10.1038/cdd.2011.107

APA

Venero, J. L., Burguillos Garcia, M., Brundin, P., & Joseph, B. (2011). The executioners sing a new song: killer caspases activate microglia. Cell Death and Differentiation, 18(11), 1679-1691. https://doi.org/10.1038/cdd.2011.107

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Author

Venero, J. L. ; Burguillos Garcia, Miguel ; Brundin, Patrik ; Joseph, B. / The executioners sing a new song: killer caspases activate microglia. I: Cell Death and Differentiation. 2011 ; Vol. 18, Nr. 11. s. 1679-1691.

RIS

TY - JOUR

T1 - The executioners sing a new song: killer caspases activate microglia

AU - Venero, J. L.

AU - Burguillos Garcia, Miguel

AU - Brundin, Patrik

AU - Joseph, B.

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)

PY - 2011

Y1 - 2011

N2 - Activation of microglia and inflammation-mediated neurotoxicity are suggested to have key roles in the pathogenesis of several neurodegenerative disorders. We recently published an article in Nature revealing an unexpected role for executioner caspases in the microglia activation process. We showed that caspases 8 and 3/7, commonly known to have executioner roles for apoptosis, can promote microglia activation in the absence of death. We found these caspases to be activated in microglia of PD and AD subjects. Inhibition of this signaling pathway hindered microglia activation and importantly reduced neurotoxicity in cell and animal models of disease. Here we review evidence suggesting that microglia can have a key role in the pathology of neurodegenerative disorders. We discuss possible underlying mechanisms regulating their activation and neurotoxic effect. We focus on the provocative hypothesis that caspase inhibition can be neuroprotective by targeting the microglia rather than the neurons themselves. Cell Death and Differentiation (2011) 18, 1679-1691; doi: 10.1038/cdd.2011.107; published online 12 August 2011

AB - Activation of microglia and inflammation-mediated neurotoxicity are suggested to have key roles in the pathogenesis of several neurodegenerative disorders. We recently published an article in Nature revealing an unexpected role for executioner caspases in the microglia activation process. We showed that caspases 8 and 3/7, commonly known to have executioner roles for apoptosis, can promote microglia activation in the absence of death. We found these caspases to be activated in microglia of PD and AD subjects. Inhibition of this signaling pathway hindered microglia activation and importantly reduced neurotoxicity in cell and animal models of disease. Here we review evidence suggesting that microglia can have a key role in the pathology of neurodegenerative disorders. We discuss possible underlying mechanisms regulating their activation and neurotoxic effect. We focus on the provocative hypothesis that caspase inhibition can be neuroprotective by targeting the microglia rather than the neurons themselves. Cell Death and Differentiation (2011) 18, 1679-1691; doi: 10.1038/cdd.2011.107; published online 12 August 2011

KW - microglia

KW - caspases

KW - neurodegenerative disorders

U2 - 10.1038/cdd.2011.107

DO - 10.1038/cdd.2011.107

M3 - Review article

C2 - 21836616

VL - 18

SP - 1679

EP - 1691

JO - Cell Death and Differentiation

JF - Cell Death and Differentiation

SN - 1350-9047

IS - 11

ER -