The feasibility of salivary sample collection in an international pediatric cohort: The the TEDDY study

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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The feasibility of salivary sample collection in an international pediatric cohort : The the TEDDY study. / Roth, Roswith; Baxter, Judith; Vehik, Kendra; Hopkins, Diane; Killian, Michael; Gesualdo, Patricia; Melin, Marie Jessica; Simell, Barbara; Strauss, Elisabeth; Lernmark, Åke; Johnson, Suzanne Bennett; TEDDY Study Group.

I: Developmental Psychobiology, Vol. 59, Nr. 5, 01.07.2017, s. 658-667.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Roth, R, Baxter, J, Vehik, K, Hopkins, D, Killian, M, Gesualdo, P, Melin, MJ, Simell, B, Strauss, E, Lernmark, Å, Johnson, SB & TEDDY Study Group 2017, 'The feasibility of salivary sample collection in an international pediatric cohort: The the TEDDY study', Developmental Psychobiology, vol. 59, nr. 5, s. 658-667. https://doi.org/10.1002/dev.21523

APA

Roth, R., Baxter, J., Vehik, K., Hopkins, D., Killian, M., Gesualdo, P., Melin, M. J., Simell, B., Strauss, E., Lernmark, Å., Johnson, S. B., & TEDDY Study Group (2017). The feasibility of salivary sample collection in an international pediatric cohort: The the TEDDY study. Developmental Psychobiology, 59(5), 658-667. https://doi.org/10.1002/dev.21523

CBE

Roth R, Baxter J, Vehik K, Hopkins D, Killian M, Gesualdo P, Melin MJ, Simell B, Strauss E, Lernmark Å, Johnson SB, TEDDY Study Group. 2017. The feasibility of salivary sample collection in an international pediatric cohort: The the TEDDY study. Developmental Psychobiology. 59(5):658-667. https://doi.org/10.1002/dev.21523

MLA

Vancouver

Author

Roth, Roswith ; Baxter, Judith ; Vehik, Kendra ; Hopkins, Diane ; Killian, Michael ; Gesualdo, Patricia ; Melin, Marie Jessica ; Simell, Barbara ; Strauss, Elisabeth ; Lernmark, Åke ; Johnson, Suzanne Bennett ; TEDDY Study Group. / The feasibility of salivary sample collection in an international pediatric cohort : The the TEDDY study. I: Developmental Psychobiology. 2017 ; Vol. 59, Nr. 5. s. 658-667.

RIS

TY - JOUR

T1 - The feasibility of salivary sample collection in an international pediatric cohort

T2 - The the TEDDY study

AU - Roth, Roswith

AU - Baxter, Judith

AU - Vehik, Kendra

AU - Hopkins, Diane

AU - Killian, Michael

AU - Gesualdo, Patricia

AU - Melin, Marie Jessica

AU - Simell, Barbara

AU - Strauss, Elisabeth

AU - Lernmark, Åke

AU - Johnson, Suzanne Bennett

AU - TEDDY Study Group

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Saliva offers a relatively noninvasive method for measuring analytes such as cortisol, holding particular promise for use in pediatric populations on a large scale if a rigorous collection protocol is feasible in diverse settings. The Environmental Determinants of Diabetes in the Young study protocol, conducted in centers in the United States, Sweden, Finland, and Germany, used salivary collection to assess cortisol level as a physiologic marker of stress. Saliva was collected using Sorbettes from subjects at 3.5, 4.5, and 5.5 years of age. Parents collected a morning sample, and staff collected pre- and post-blood draw samples. Feasibility was assessed based on protocol completion, adherence with instructions, factors affecting adherence, and sufficiency of saliva sample for cortisol determination. Collection of saliva samples in a diverse pediatric population is feasible. Establishing non-invasive and acceptable methods for collecting physiological parameters of stress will allow better exploration of determinants of health in this important population.

AB - Saliva offers a relatively noninvasive method for measuring analytes such as cortisol, holding particular promise for use in pediatric populations on a large scale if a rigorous collection protocol is feasible in diverse settings. The Environmental Determinants of Diabetes in the Young study protocol, conducted in centers in the United States, Sweden, Finland, and Germany, used salivary collection to assess cortisol level as a physiologic marker of stress. Saliva was collected using Sorbettes from subjects at 3.5, 4.5, and 5.5 years of age. Parents collected a morning sample, and staff collected pre- and post-blood draw samples. Feasibility was assessed based on protocol completion, adherence with instructions, factors affecting adherence, and sufficiency of saliva sample for cortisol determination. Collection of saliva samples in a diverse pediatric population is feasible. Establishing non-invasive and acceptable methods for collecting physiological parameters of stress will allow better exploration of determinants of health in this important population.

KW - adherence

KW - methodological feasibility

KW - multi-center international

KW - pediatric cohort study

KW - salivary collection

KW - salivary cortisol

U2 - 10.1002/dev.21523

DO - 10.1002/dev.21523

M3 - Article

C2 - 28555778

AN - SCOPUS:85019740807

VL - 59

SP - 658

EP - 667

JO - Developmental Psychobiology

JF - Developmental Psychobiology

SN - 0012-1630

IS - 5

ER -