The growth hormone receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general population.

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Bibtex

@article{48b1e4f133fe4acaac2244c8ca6ea610,
title = "The growth hormone receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general population.",
abstract = "Objective: To test the hypothesis that the growth hormone (GH) receptor (GHR) d3/fl polymorphism influences anthropometry and body composition in the general population. Design and Setting: The Swedish Obese Subjects (SOS) reference study is a cross-sectional population-based study, randomly selected from a population registry. A sub-group of the population-based Malm{\"o} Diet and Cancer Study (MDC-CC) was used as a replication cohort. Methods: The SOS reference study comprises 1135 subjects (46.2{\%} men), with an average age of 49.5 yrs. The MDC-CC includes 5451 successfully genotyped subjects (41.5{\%} men), with an average age of 57.5 yrs. GHR d3/fl genotypes were determined using tagSNP rs6873545. Linear regression analyses were used to test for genotype - phenotype associations. Results: In the SOS reference study, subjects homozygous for the d3-GHR weighed approximately four kilos more (p=0.011), had larger waist-to-hip ratio (WHR, p=0.036), waist circumference (p=0.016) and more fat free mass estimated from total body potassium (TBK, p=0.026) than grouped fl/d3 and fl/fl subjects (d3-recessive genetic model). The association with WHR was replicated in the MDC-CC (p=0.002), but not those with other anthropometric traits. Conclusions: In this population-based study the GHR d3/fl polymorphism was found to be of functional relevance and associated with central adiposity, such that subjects homozygous for the d3-GHR showed an increased abdominal obesity.",
author = "Glad, {Camilla A M} and Carlsson, {Lena M S} and Olle Melander and Peter Almgren and Lars Sj{\"o}str{\"o}m and Staffan Nilsson and Ingrid Larsson and Per-Arne Svensson and Gudmundur Johannsson",
year = "2015",
doi = "10.1530/EJE-14-0723",
language = "English",
volume = "172",
journal = "European Journal of Endocrinology",
issn = "1479-683X",
publisher = "Society of the European Journal of Endocrinology",
number = "2",

}