The growth hormone receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general population.

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The growth hormone receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general population. / Glad, Camilla A M; Carlsson, Lena M S; Melander, Olle; Almgren, Peter; Sjöström, Lars; Nilsson, Staffan; Larsson, Ingrid; Svensson, Per-Arne; Johannsson, Gudmundur.

I: European Journal of Endocrinology, Vol. 172, Nr. 2, 2015.

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Glad, Camilla A M ; Carlsson, Lena M S ; Melander, Olle ; Almgren, Peter ; Sjöström, Lars ; Nilsson, Staffan ; Larsson, Ingrid ; Svensson, Per-Arne ; Johannsson, Gudmundur. / The growth hormone receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general population. I: European Journal of Endocrinology. 2015 ; Vol. 172, Nr. 2.

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TY - JOUR

T1 - The growth hormone receptor exon 3 deleted/full-length polymorphism is associated with central adiposity in the general population.

AU - Glad, Camilla A M

AU - Carlsson, Lena M S

AU - Melander, Olle

AU - Almgren, Peter

AU - Sjöström, Lars

AU - Nilsson, Staffan

AU - Larsson, Ingrid

AU - Svensson, Per-Arne

AU - Johannsson, Gudmundur

PY - 2015

Y1 - 2015

N2 - Objective: To test the hypothesis that the growth hormone (GH) receptor (GHR) d3/fl polymorphism influences anthropometry and body composition in the general population. Design and Setting: The Swedish Obese Subjects (SOS) reference study is a cross-sectional population-based study, randomly selected from a population registry. A sub-group of the population-based Malmö Diet and Cancer Study (MDC-CC) was used as a replication cohort. Methods: The SOS reference study comprises 1135 subjects (46.2% men), with an average age of 49.5 yrs. The MDC-CC includes 5451 successfully genotyped subjects (41.5% men), with an average age of 57.5 yrs. GHR d3/fl genotypes were determined using tagSNP rs6873545. Linear regression analyses were used to test for genotype - phenotype associations. Results: In the SOS reference study, subjects homozygous for the d3-GHR weighed approximately four kilos more (p=0.011), had larger waist-to-hip ratio (WHR, p=0.036), waist circumference (p=0.016) and more fat free mass estimated from total body potassium (TBK, p=0.026) than grouped fl/d3 and fl/fl subjects (d3-recessive genetic model). The association with WHR was replicated in the MDC-CC (p=0.002), but not those with other anthropometric traits. Conclusions: In this population-based study the GHR d3/fl polymorphism was found to be of functional relevance and associated with central adiposity, such that subjects homozygous for the d3-GHR showed an increased abdominal obesity.

AB - Objective: To test the hypothesis that the growth hormone (GH) receptor (GHR) d3/fl polymorphism influences anthropometry and body composition in the general population. Design and Setting: The Swedish Obese Subjects (SOS) reference study is a cross-sectional population-based study, randomly selected from a population registry. A sub-group of the population-based Malmö Diet and Cancer Study (MDC-CC) was used as a replication cohort. Methods: The SOS reference study comprises 1135 subjects (46.2% men), with an average age of 49.5 yrs. The MDC-CC includes 5451 successfully genotyped subjects (41.5% men), with an average age of 57.5 yrs. GHR d3/fl genotypes were determined using tagSNP rs6873545. Linear regression analyses were used to test for genotype - phenotype associations. Results: In the SOS reference study, subjects homozygous for the d3-GHR weighed approximately four kilos more (p=0.011), had larger waist-to-hip ratio (WHR, p=0.036), waist circumference (p=0.016) and more fat free mass estimated from total body potassium (TBK, p=0.026) than grouped fl/d3 and fl/fl subjects (d3-recessive genetic model). The association with WHR was replicated in the MDC-CC (p=0.002), but not those with other anthropometric traits. Conclusions: In this population-based study the GHR d3/fl polymorphism was found to be of functional relevance and associated with central adiposity, such that subjects homozygous for the d3-GHR showed an increased abdominal obesity.

U2 - 10.1530/EJE-14-0723

DO - 10.1530/EJE-14-0723

M3 - Article

VL - 172

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 1479-683X

IS - 2

ER -