The Human Diabetes Proteome Project (HDPP): The 2014 update

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.

Detaljer

Författare
  • D. Schvartz
  • Patrik Bergsten
  • K. H. Baek
  • A. Barba De La Rosa
  • J. Cantley
  • L. Dayon
  • F. Finamore
  • P. Fontana
  • P. Gaudet
  • Y. A. Goo
  • R. Moulder
  • David R Goodlett
  • J. D. Johnson
  • A. Konvalinka
  • F. Priego-Capote
  • Salvatore Sechi
  • Kathleen M. Snyder
  • A. Tiss
  • A. Wiederkehr
  • I. Xenarios
  • Martin Kussmann
Enheter & grupper
Externa organisationer
  • University of Geneva
  • Uppsala universitet, Historiska institutionen
  • University of Oxford
  • Swiss Federal Institute of Technology
  • Geneva University Hospital
  • Swiss Institute of Bioinformatics
  • University of Turku
  • University of British Columbia
  • University of Toronto
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • Stanford University
  • Dasman Diabetes Institute
  • CHA University
  • Instituto Potosino de Investigación Científica y Tecnológica
  • University of Maryland
  • University of Córdoba, Spain
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Endokrinologi och diabetes
  • Cell- och molekylärbiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)1-7
Antal sidor7
TidskriftTranslational Proteomics
Volym8-9
StatusPublished - 2015 dec 1
PublikationskategoriForskning
Peer review utfördJa