The influence of the major histocompatibility complex (H-2) on experimental diabetes in mice

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Mice with different histocompatibility loci on an identical background genome (congenic resistant lines of mice) were used to study the possible influence of the histocompatibility complex on experimental diabetes. The major histocompatibility complex (H-2) was not found to influence the diabetogenic effect of encephalomyocarditis (EMC) virus. In contrast the glucose intolerance following heterologous and homologous immunization with pancreatic antigens appeared H-2 influenced. Antibodies against cell surface components on viable B-cells were present in serum from mice with glucose intolerance induced by homologous immunization. The results suggest that the susceptibility to experimental autoimmune diabetes in mice is influenced by the H-2 complex.

Detaljer

Författare
  • H. Kromann
  • Å Lernmark
  • B. F. Vestergaard
  • J. Egeberg
  • J. Nerup
Externa organisationer
  • Steno Diabetes Center
  • Umeå University
  • University of Copenhagen
Forskningsområden

Nyckelord

Originalspråkengelska
Sidor (från-till)107-114
Antal sidor8
TidskriftDiabetologia
Volym16
Utgåva nummer2
StatusPublished - 1979 feb 1
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa