The intracellular distribution of Cobalt in exposed and unexposed rat myocardium

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The intracellular distribution of cobalt was analysed in the myocardium of exposed and unexposed rats. The exposed rats were given a dietary cobalt supplementation of 40 mg CoS04-7 H20/kg body weight for 8 weeks. The mitochondrial fraction showed the greatest relative increase in cobalt: 0.09 ng/mg protein in the unexposed rats to 8.43 ng/mg protein in the exposed rats. In the exposed rats the submitochondrial particles had the highest levels of cobalt: 19.43 ng/mg protein, followed by the sarcoplasmatic reticulum: 12.3 ng/mg protein. The microsomal 44 000g supernatant also showed an increase, although the levels remained low (0.51 ng/mg protein in the exposed animals). Apparently the calcium-storing organelles had the highest levels of cobalt. This could affect calcium flux in myocardial cells and, secondarily, tension development in cardiac muscle.

Detaljer

Författare
  • N. Clyne
  • B. Persson
  • N. Havu
  • E. Hultman
  • L. E. Lins
  • S. K. Pehrsson
  • J. Rydstrom
  • R. Wibom
Externa organisationer
  • Karolinska University Hospital
  • Stockholms universitet
Forskningsområden

Nyckelord

Originalspråkengelska
Sidor (från-till)605-609
Antal sidor5
TidskriftScandinavian Journal of Clinical & Laboratory Investigation
Volym50
Utgivningsnummer6
StatusPublished - 1990
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa