The involvement of cellular proliferation status in the expression of the human proto-oncogene DEK

Forskningsoutput: TidskriftsbidragLetter

Abstract

The role of the DEK protein, involved in the leukemia-associated fusion protein DEK-CAN, is not yet known. In this study, we show a higher expression of DEK mRNA in immature cells than in mature cells. Furthermore, a correlation between DEK expression and cell proliferation was demonstrated, suggesting that DEK plays a role in the proliferation of hematopoietic cells and raising the question of whether the DEK-CAN fusion protein might perturb regulation of proliferation in leukemic cells.

Detaljer

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Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Hematologi

Nyckelord

Originalspråkengelska
Sidor (från-till)268-269
TidskriftHaematologica
Volym91
Utgivningsnummer2
StatusPublished - 2006
PublikationskategoriForskning
Peer review utfördNej