The involvement of cellular proliferation status in the expression of the human proto-oncogene DEK

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The involvement of cellular proliferation status in the expression of the human proto-oncogene DEK. / Ageberg, Malin; Gullberg, Urban; Lindmark, Anders.

I: Haematologica, Vol. 91, Nr. 2, 2006, s. 268-269.

Forskningsoutput: TidskriftsbidragLetter

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TY - JOUR

T1 - The involvement of cellular proliferation status in the expression of the human proto-oncogene DEK

AU - Ageberg, Malin

AU - Gullberg, Urban

AU - Lindmark, Anders

PY - 2006

Y1 - 2006

N2 - The role of the DEK protein, involved in the leukemia-associated fusion protein DEK-CAN, is not yet known. In this study, we show a higher expression of DEK mRNA in immature cells than in mature cells. Furthermore, a correlation between DEK expression and cell proliferation was demonstrated, suggesting that DEK plays a role in the proliferation of hematopoietic cells and raising the question of whether the DEK-CAN fusion protein might perturb regulation of proliferation in leukemic cells.

AB - The role of the DEK protein, involved in the leukemia-associated fusion protein DEK-CAN, is not yet known. In this study, we show a higher expression of DEK mRNA in immature cells than in mature cells. Furthermore, a correlation between DEK expression and cell proliferation was demonstrated, suggesting that DEK plays a role in the proliferation of hematopoietic cells and raising the question of whether the DEK-CAN fusion protein might perturb regulation of proliferation in leukemic cells.

KW - leukemia

KW - DEK

KW - proliferation

M3 - Letter

VL - 91

SP - 268

EP - 269

JO - Haematologica-The Hematology Journal

T2 - Haematologica-The Hematology Journal

JF - Haematologica-The Hematology Journal

SN - 1592-8721

IS - 2

ER -