The Kärger vs bi-exponential model: Theoretical insights and experimental validations

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title = "The K{\"a}rger vs bi-exponential model: Theoretical insights and experimental validations",
abstract = "We revise three common models accounting for water exchange in pulsed-gradient spin-echo measurements: a bi-exponential model with time-dependent water fractions, the K{\"a}rger model, and a modified K{\"a}rger model designed for restricted diffusion, e.g. inside cells. The three models are compared and applied to experimental data from yeast cell suspensions. The K{\"a}rger model and the modified K{\"a}rger model yield very close results and accurately fit the data. The bi-exponential model, although less rigorous, has a natural physical interpretation and suggests a new experimental modality to estimate the water exchange time.",
keywords = "Bi-exponential model, K{\"a}rger model, Permeability, PGSE, Water exchange, Yeast cells",
author = "Nicolas Moutal and Markus Nilsson and Daniel Topgaard and Denis Grebenkov",
year = "2018",
doi = "10.1016/j.jmr.2018.08.015",
language = "English",
volume = "296",
pages = "72--78",
journal = "Journal of Magnetic Resonance",
issn = "1096-0856",
publisher = "Academic Press",