The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The activated forms of the complement lectin pathway (LP) proteases MASP-1 and -2 are able to cleave the coagulation factors prothrombin, fibrinogen, factor XIII and TAFI in vitro. In vivo studies also show that MASP-1 is involved in thrombogenesis, OBJECTIVES: To clarify the not yet identified mechanisms involved in triggering activation of the LP during thrombotic reactions.

Detaljer

Författare
  • Huda Kozarcanin
  • Christian Lood
  • Lea Munthe-Fog
  • Kerstin Sandholm
  • Osama A Hamad
  • Anders Bengtsson
  • Mikkel-Ole Skjoedt
  • Markus Huber-Lang
  • Peter Garred
  • Kristina N Ekdahl
  • Bo Nilsson
Enheter & grupper
Externa organisationer
  • Uppsala universitet, Historiska institutionen
  • University of Copenhagen
  • Linnaeus University
  • University Hospital of Ulm
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Hematologi
Originalspråkengelska
Sidor (från-till)531-545
TidskriftJournal of Thrombosis and Haemostasis
Volym14
Utgivningsnummer3
Tidigt onlinedatum2015 nov 28
StatusPublished - 2016
PublikationskategoriForskning
Peer review utfördJa