The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases

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Abstract

Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine proteases. We also discuss how this finding can be reconciled with the apparently contradictory experimental results.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Warsaw University of Life Sciences
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cell- och molekylärbiologi
  • Annan klinisk medicin

Nyckelord

Originalspråkengelska
Artikelnummere3849
TidskriftPeerJ
Volym2017
Utgåva nummer9
StatusPublished - 2017
PublikationskategoriForskning
Peer review utfördJa