The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.

Detaljer

Författare
  • Evald Rosengren
  • Pierre Åman
  • Sofia Thelin
  • Christer Hansson
  • Stefan Ahlfors
  • Peter Björk
  • Lars Jacobsson
  • Hans Rorsman
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Biologiska vetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)85-88
TidskriftFEBS Letters
Volym417
Utgåva nummer1
StatusPublished - 1997
PublikationskategoriForskning
Peer review utfördJa