The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This review will summarize the “A, T, N System” (Amyloid, Tau, and Neurodegeneration) using biomarkers and how this may be applied to clinical research and drug development. In addition, challenges and barriers to the potential adoption of this new framework will be discussed. Finally, future directions for research will be proposed.

Detaljer

Författare
  • David S. Knopman
  • Samantha Budd Haeberlein
  • Maria C. Carrillo
  • James A. Hendrix
  • Geoff Kerchner
  • Richard Margolin
  • Paul Maruff
  • David S. Miller
  • Gary Tong
  • Maria B. Tome
  • Melissa E. Murray
  • Peter T. Nelson
  • Mary Sano
  • David L. Sultzer
  • Thomas J. Montine
  • Clifford R. Jack
  • Hartmuth Kolb
  • Ronald C. Petersen
  • Prashanthi Vemuri
  • Megan Zoschg Canniere
  • Julie A. Schneider
  • Susan M. Resnick
  • Gary Romano
  • Argonde Corien van Harten
  • David A. Wolk
  • Lisa J. Bain
  • Eric Siemers
Enheter & grupper
Externa organisationer
  • Mayo Clinic Minnesota
  • Biogen, Inc.
  • Alzheimer's Association: Alzheimer's Disease and Dementia
  • Genentech, Inc
  • Pfizer
  • European Medicines Agency (EMA)
  • Mayo Clinic Florida
  • University of Kentucky
  • Icahn School of Medicine at Mount Sinai
  • Stanford University
  • Janssen Research & Development LLC
  • F. Hoffmann-La Roche AG
  • Rush University Medical Center Chicago
  • National Institute on Aging, United States
  • VU University Medical Center
  • University of Pennsylvania
  • Lilly Research Laboratories
  • Cogstate Ltd
  • Bracket
  • Lundbeck US
  • University of California, Los Angeles
  • No affiliation available (private)
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi

Nyckelord

Originalspråkengelska
Sidor (från-till)563-575
Antal sidor13
TidskriftAlzheimer's and Dementia
Volym14
Utgivningsnummer4
StatusPublished - 2018 apr 1
PublikationskategoriForskning
Peer review utfördJa