The PanCareSurFup cohort of 83,333 five-year survivors of childhood cancer: a cohort from 12 European countries

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Childhood cancer survivors face risks from a variety of late effects, including cardiac events, second cancers, and late mortality. The aim of the pan-European PanCare Childhood and Adolescent Cancer Survivor Care and Follow-Up Studies (PanCareSurFup) Consortium was to collect data on incidence and risk factors for these late effects among childhood cancer survivors in Europe. This paper describes the methodology of the data collection for the overall PanCareSurFup cohort and the outcome-related cohorts. In PanCareSurFup 13 data providers from 12 countries delivered data to the data centre in Mainz. Data providers used a single variable list that covered all three outcomes. After validity and plausibility checks data was provided to the outcome-specific working groups. In total, we collected data on 115,596 patients diagnosed with cancer from 1940 to 2011, of whom 83,333 had survived 5 years or more. Due to the eligibility criteria and other requirements different numbers of survivors were eligible for the analysis of each of the outcomes. Thus, 1014 patients with at least one cardiac event were identified from a cohort of 39,152 5-year survivors; for second cancers 3995 survivors developed at least one second cancer from a cohort of 71,494 individuals, and from the late mortality cohort of 79,441 who had survived at least 5 years, 9247 died subsequently. Through the close cooperation of many European countries and the establishment of one central data collection and harmonising centre, the project succeeded in generating the largest cohort of children with cancer to date.


  • Desiree Grabow
  • Melanie Kaiser
  • Julianne Byrne
  • Daniela Alessi
  • Rodrigue S. Allodji
  • Francesca Bagnasco
  • Edit Bárdi
  • Andrea Bautz
  • Chloe J. Bright
  • Florent de Vathaire
  • Elizabeth A.M. Feijen
  • Stanislaw Garwicz
  • Riccardo Haupt
  • Mike M. Hawkins
  • Zsuzsanna Jakab
  • Leontien C.M. Kremer
  • Claudia E. Kuehni
  • Rahel Kuonen
  • Päivi Maria Lähteenmäki
  • Raoul C. Reulen
  • Cécile M. Ronckers
  • Carlotta Sacerdote
  • Giao Vu-Bezin
  • Finn Wesenberg
  • David L. Winter
  • Jeanette Falck Winther
  • Lorna Zadravec Zaletel
  • Peter Kaatsch
Enheter & grupper
Externa organisationer
  • Universitätsmedizin Mainz
  • Skåne University Hospital
  • Boyne Research Institute
  • Citta' della Salute e della Scienza Hospital-University of Turin
  • Gaslini Children's Hospital
  • Semmelweis University
  • Danish Cancer Society Research Center
  • University of Birmingham
  • Academic Medical Center
  • Turku University Hospital
  • Oslo university hospital
  • Institute of Oncology, Ljubljana
  • University of Paris-Saclay
  • Kepler Universitätsklinikum
  • Regional Cancer Center South, Lund
  • Princess Maxima Center for Pediatric Oncology/Hematology
  • University of Bern

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi


Sidor (från-till)335-349
Antal sidor15
TidskriftEuropean Journal of Epidemiology
Utgåva nummer3
Tidigt onlinedatum2018 mar 2
StatusPublished - 2018 mar
Peer review utfördJa