The preservative 2-(thiocyanomethylthio)benzothiazole: A potential allergen in leather products

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The preservative 2-(thiocyanomethylthio)benzothiazole : A potential allergen in leather products. / Herman, Anne; Goossens, An; Tennstedt, Dominique; Bergendorff, Ola; Isaksson, Marléne; Mowitz, Martin; Baeck, Marie.

I: Contact Dermatitis, Vol. 81, Nr. 4, 2019, s. 262-265.

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TY - JOUR

T1 - The preservative 2-(thiocyanomethylthio)benzothiazole

T2 - A potential allergen in leather products

AU - Herman, Anne

AU - Goossens, An

AU - Tennstedt, Dominique

AU - Bergendorff, Ola

AU - Isaksson, Marléne

AU - Mowitz, Martin

AU - Baeck, Marie

PY - 2019

Y1 - 2019

N2 - Background: Allergic contact dermatitis caused by leather is common, and several responsible allergens, such as tanning agents, glues, mercaptobenzothiazole derivatives, and dyes, but also antimicrobials and antifungals, are involved. Material and methods: Three female patients were referred to the Departments of Dermatology in a Belgian university hospital following skin reactions caused by leather products (shoes, belt, and car seats). They were patch tested with the European baseline series and samples of suspected leather products, and additionally with 2-(thiocyanomethylthio)benzothiazole (TCMTB), an antifungal agent previously reported to be a contact allergen in footwear. Chromatographic analyses of samples of all the leather materials tested were performed at the Department of Occupational and Environmental Dermatology in Malmö, Sweden. Results: The patients reacting to the leather samples were shown to be sensitized to TCMTB, the presence of which could be confirmed by chemical analyses of samples obtained from the patients. Conclusion: Patch tests with TCMTB should be considered in patients with contact dermatitis caused by leather items.

AB - Background: Allergic contact dermatitis caused by leather is common, and several responsible allergens, such as tanning agents, glues, mercaptobenzothiazole derivatives, and dyes, but also antimicrobials and antifungals, are involved. Material and methods: Three female patients were referred to the Departments of Dermatology in a Belgian university hospital following skin reactions caused by leather products (shoes, belt, and car seats). They were patch tested with the European baseline series and samples of suspected leather products, and additionally with 2-(thiocyanomethylthio)benzothiazole (TCMTB), an antifungal agent previously reported to be a contact allergen in footwear. Chromatographic analyses of samples of all the leather materials tested were performed at the Department of Occupational and Environmental Dermatology in Malmö, Sweden. Results: The patients reacting to the leather samples were shown to be sensitized to TCMTB, the presence of which could be confirmed by chemical analyses of samples obtained from the patients. Conclusion: Patch tests with TCMTB should be considered in patients with contact dermatitis caused by leather items.

KW - 2-(thiocyanomethylthio)benzothiazole

KW - allergic contact dermatitis

KW - antifungal

KW - antimicrobial

KW - CAS no. 21564-17-0

KW - chemical analysis

KW - cross-reactions

KW - footwear

KW - leather

KW - preservative

U2 - 10.1111/cod.13295

DO - 10.1111/cod.13295

M3 - Article

C2 - 31006870

AN - SCOPUS:85066487758

VL - 81

SP - 262

EP - 265

JO - Contact Dermatitis

JF - Contact Dermatitis

SN - 0105-1873

IS - 4

ER -