The Prevalence and Determinants of Neuropsychiatric Symptoms in Late-Stage Parkinsonism

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Background: Late-stage parkinsonism and Parkinson's disease (PD) are insufficiently studied population. Although neuropsychiatric symptoms (eg, psychosis, depression, anxiety, behavioral problems) are frequently present, their prevalence and clinical predictors remain unknown. Objective: To determine the prevalence and predictors of neuropsychiatric symptoms in late-stage PD. Methods: We conducted a multinational study of patients with PD with ≥7 years disease duration and either a Hoehn and Yahr stage ≥4 or a Schwab and England score ≤ 50% in the on stage. Neuropsychiatric symptoms were assessed through interviews with carers using the Neuropsychiatric Inventory, with a frequency × severity score ≥ 4, indicating clinically relevant symptoms. The determinants analyzed were demographic characteristics, medication, and motor and nonmotor symptoms. Univariate and multivariate logistic analyses were performed on predictors of clinically relevant neuropsychiatric symptoms. Results: A total of 625 patients were recruited in whom the Neuropsychiatric Inventory could be completed. In 92.2% (576/625) of the patients, at least 1 neuropsychiatric symptom was present, and 75.5% (472/625) had ≥1 clinically relevant symptom. The most common clinically relevant symptoms were apathy (n = 242; 38.9%), depression (n = 213; 34.5%), and anxiety (n = 148; 23.8%). The multivariate analysis revealed unique sets of predictors for each symptom, particularly the presence of other neuropsychiatric features, cognitive impairment, daytime sleepiness. Conclusion: Neuropsychiatric symptoms are common in late-stage PD. The strongest predictors are the presence of other neuropsychiatric symptoms. Clinicians involved in the care for patients with late-stage PD should be aware of these symptoms in this specific disease group and proactively explore other psychiatric comorbidities once a neuropsychiatric symptom is recognized.


  • Adrianus L.A.J. Hommel
  • Marjan J. Meinders
  • Stefan Lorenzl
  • Richard Dodel
  • Miguel Coelho
  • Joaquim J. Ferreira
  • Brice Laurens
  • Umberto Spampinato
  • Wassilios Meissner
  • Kristina Rosqvist
  • Jonathan Timpka
  • Per Odin
  • Michael Wittenberg
  • Bas R. Bloem PhD
  • Raymond T. Koopmans
  • Anette Schrag
  • Care of Late-Stage Parkinsonism Consortium
Enheter & grupper
Externa organisationer
  • Radboud University Medical Center
  • University Hospital Essen
  • University of Lisbon
  • Santa Maria Hospital, Lisbon
  • Centre Hospitalier Universitaire de Bordeaux
  • University of Bordeaux
  • University of Otago
  • Philipp University of Marburg
  • University College London
  • Groenhuysen
  • Ludwig-Maximilian University of Munich
  • University Hospital Munich
  • Paracelsus Private Medical University of Salzburg
  • New Zealand Brain Research Institute
  • Joachim en Anna, Center for Specialized Geriatric Care

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurologi
  • Geriatrik


Sidor (från-till)531-542
Antal sidor12
TidskriftMovement Disorders Clinical Practice
Utgåva nummer5
Tidigt onlinedatum2020 apr 27
StatusPublished - 2020 jul
Peer review utfördJa